Ethyl2-fluoropropionate

Clear colorless to light yellow liquid

In a 2 L four-necked flask equipped with a condenser, DMF 1100 g, 273 g (2.0 mol) of ethyl 2-chloropropionate, Tetrabutylammonium bromide 54g, Triethyl orthoformate 5.5g, 255.2 g of potassium fluoride, Stirring, Warmed to 100 ° C, Reaction 12h.After the reaction, distillation, 176.3 g of ethyl 2-fluoropropionate was obtained, Purity 99.5percent; Yield 66.5percent.(1) Placed tetrafluoroethyl dimethylamine (TFEDMA)500ml PTFE-lined reactor with condensing tube, Slowly drip ethyl lactate at 0 ° C, The molar ratio of tetrafluoroethyldimethylamine to ethyl lactate is 1.2:1, The temperature of the control system is below 10 °C.After the addition, it will rise to 50 °C.Stir for 4h, The reaction is over, Cool down to 0 ° C, Join slowly4-N, N-dimethylpyridine (C7H10N2), The molar ratio of 4-N, N-lutidine to tetrafluoroethyldimethylamine is 0.3:1, Reduced distillationChlorosulfonic acid (660 mL, 10 mol, 20 eq) was added to a solution ofphthaloyldichloride (1.4 L, 10 mol, 20 eq) and ethyl-2-fluoropropanoate (600 g, 5 mol) at room temperature.The solution was heated at 120 'C for 4 hs. 2-(R)-fluoropropanoyl chloride was distilled from thereaction mixture under reduced pressure and recovered as a colourless oil (320 g, 58.2percent). 1HNMR(CDCl3, 400 MHz): 8 5.08 (dq, J = 48.8, 6.8 Hz, 1 H), 1.63 (dd, J =22.8, 6.8 Hz, 3 H).In a 2 L four-necked flask equipped with a condenser, DMF 1100 g, 273 g (2.0 mol) of ethyl 2-chloropropionate, Tetrabutylammonium bromide 54g, Triethyl orthoformate 5.5g, 255.2 g of potassium fluoride, Stirring, Warmed to 100 ° C, Reaction 12h.After the reaction, distillation, 176.3 g of

Molecular Weight:120.12
XLogP3:0.8
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:120.05865769
Monoisotopic Mass:120.05865769
Topological Polar Surface Area:26.3
Heavy Atom Count:8
Complexity:82.5
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes