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Home > Encyclopedia > Sebacic acid

Sebacic acid

pharmaceutical raw materials
Sebacic acid structure

Sebacic acid 

structure
  • CAS No:

    111-20-6

  • Formula:

    C10H18O4

  • Chemical Name:

    Sebacic acid

  • Synonyms:

    Decanedioic acid;Sebacic acid;1,8-Octanedicarboxylic acid;1,10-Decanedioic acid;n-Decanedioic acid;NSC 19492;NSC 97405

  • Categories:

    Cosmetic Ingredient  >  Buffering

Description

Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.


Sebacic acid is a white granular powder. Melting point 153°F. Slightly soluble in water. Sublimes slowly at 750 mm Hg when heated to melting point.|DryPowder; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals|Solid|WHITE POWDER WITH CHARACTERISTIC ODOUR.


Sebacic acid is a white granular powder. Melting point 153°F. Slightly soluble in water. Sublimes slowly at 750 mm Hg when heated to melting point.|Sebacic acid is an alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. It has a role as a human metabolite and a plant metabolite. It is an alpha,omega-dicarboxylic acid and a lipid. It is a conjugate acid of a sebacate(2-) and a sebacate. It derives from a hydride of a decane.

Sebacic acid Basic Attributes

202.24800

202.25

203-845-5

97AN39ICTC

1685

19492

DTXSID7026867

2917131000

Characteristics

74.60000

2.1

White powder

1.231 g/cm3

130.8 °C

294.5 °C

220 °C

1.422

Solubility in water, g/100ml: 0.1 (poor)

Storage Room low temperature ventilation drying

1.24E-06mmHg at 25°C

141.9 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|152.7 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|144 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|146 Ų [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|146.3 Ų [M-2H+Na]-

Insoluble in water.

Acids, Carboxylic

SEBACIC ACID reacts exothermically to neutralize bases, both organic and inorganic. May react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Can react with active metals to form gaseous hydrogen and a metal salt. Such reactions are slow in the dry, but systems may absorb enough water from the air to allow corrosion of iron, steel, and aluminum parts and containers. Reacts slowly with cyanide salts to generate gaseous hydrogen cyanide. Reacts with solutions of cyanides to cause the release of gaseous hydrogen cyanide. May generate flammable and/or toxic gases and heat with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. May react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Can be oxidized exothermically by strong oxidizing agents and reduced by strong reducing agents. May initiate polymerization reactions.

Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.

Safety Information

NONH for all modes of transport

1

R36/37/38

S26-S36

VS0875000

Xi

Separated from strong oxidants and strong bases.

Stable. Combustible. Incompatible with strong oxidizing agents, bases, reducing agents.

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

Flash point data for this compound are not available. It is probably combustible. (NTP, 1992)|Combustible. Finely dispersed particles form explosive mixtures in air.

Not Classified| |Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)|Use foam, dry powder, carbon dioxide.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Separated from strong oxidants and strong bases.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

NO open flames. Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting.

PREVENT DISPERSION OF DUST!

Use local exhaust.

Protective gloves.

Wear safety spectacles.

Drug Information

SYMPTOMS: This compound may cause irritation. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)


Fresh air, rest.


Rinse and then wash skin with water and soap.


Rinse with plenty of water (remove contact lenses if easily possible).

sebacic acid

The substance can be absorbed into the body by ingestion.

Sebacic acid Use and Manufacturing

Methods of Manufacturing

Natural castor oil or adipic acid ester as raw materials in the system. With ethylene, carbon tetrachloride by polymerization can also be sebacic acid, but the world's industrial production of sebacic acid is almost all castor oil as raw materials.
1.castor oil cracking method Castor oil heated under alkaline hydrolysis of sodium soap castor oil, sulfuric acid and then add acid hydrolysis of ricinoleic acid; in the presence of diluent cresol, alkali heated to 260-280 ℃ for cracking , The formation of sebacic acid sodium salt and secondary octanol and hydrogen, the lysate diluted by water, heating and acid and the double sodium salt into a single sodium salt; and then activated carbon decolorization after boiling liquid and acid, Sebacic acid monosodium salt into sebacic acid crystallization, and then by separation, drying derived products. Raw materials consumption quota: castor oil (industrial products) 2100kg / t, sulfuric acid (98%) 1600kg / t, caustic soda (95%) 1200kg / t, cresol (industrial products) 100kg / t.
2.n-decane oil fermentation method using 200 # solvent oil or 166-182 ° C fraction obtained in the separation of n-decane, to 19-2 Candida lipolytic fermentation system in sebacic acid.
3. the new cyclopentanone method to palladium salt - copper or iron as a catalyst in ethanol, propanol or other alcohols in the solvent, at 40-60 ℃ low temperature and atmospheric pressure conditions, the cyclopentene with air oxidation Cyclopentanone, and then with iron catalyst oxidation and dimerization.
4. Tobacco: OR, 44; BU, 18; FC, 54.

Uses

Raw material in the production of synthetic resins of the alkylated or polyester type, non-migrating plasticizers, polyester rubbers, synthetic fibers of the polyamide type.


Adhesives and sealant chemicals


Adhesives and sealants

Production

10,000,000 - 50,000,000 lb

Adhesive manufacturing|Decanedioic acid: ACTIVE|Decanedioic acid, homopolymer: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Agrochemicals -> Repellants|Fatty Acyls [FA] -> Fatty Acids and Conjugates [FA01] -> Dicarboxylic acids [FA0117]|Cosmetics -> Buffering

Computed Properties

Molecular Weight:202.25
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:202.12050905
Monoisotopic Mass:202.12050905
Topological Polar Surface Area:74.6
Heavy Atom Count:14
Complexity:157
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Price Analysis

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