Coenzyme Q10

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

1. Coenzyme Q10 can be produced by synthesis and microbial fermentation. Can also be extracted from porcine myocardium. 2. Swine myocardial slag saponification of quick cooling saponification ↓ gasoline extraction 3. Washed decompression concentrated filter chromatography 4. Crystallization of coenzyme Q10 was concentrated under reduced pressure 5. Cytochrome C extraction of the heart after the residue, to remove the water rinse (N. H4) 2SO4 and fat, dry, add coke gallic acid and mix well. Another about two times the amount of ethanol in the refluxing tank, plus solid caustic soda, stirring dissolved, the preparation of the alkali concentration of about 10% (mass concentration) of alcohol base solution, and then into the heart of mixed with coke gallic acid residue, rapid Heated to boiling, reflux 25 ~ 30min saponification. And then quickly cooled to room temperature, in the saponification of the cooling, the right amount of gasoline added 120, extraction three times, so that extraction is complete, the combined extract, washed repeatedly with water to near neutral. The washed extract was concentrated to about 1/10 of the original volume under reduced pressure, and the precipitated impurities (mainly cholesterol) were removed by low-temperature filtration. The clear filtrate was added to a silica gel column. The debris was washed with petrol No. 120 and eluted with a mixture of ether and petrol (1:10, volume fraction). The eluent of the yellow stripped portion was collected. In the yellow oil-like eluent, add an appropriate amount of ethanol, warm to dissolve completely. Filtered hot, the filtrate into the refrigerator to make the crystal completely. Filtration crystallization, recrystallization in anhydrous ethanol or silica gel column re-chromatography, can get a higher purity of coenzyme Q10. 6. In addition to the above saponification method, there are solvent extraction and solvent extraction saponification method. The yield of the solvent extraction method is not as good as the saponification method, but the province uses coke gallic acid in addition. Larger amounts of pyrogallic acid may produce ethoxylated derivatives during the saponification process and may also be charged with nitrogen during saponification. N-hexane, n-heptane, isooctane, cyclohexane, ether and ethanol and ether mixed solvent can be used to extract coenzyme Q10. Chromatography of the adsorbent can be purified silica gel and alumina. 7. Tobacco: FC, BU, 1.

1. Coenzyme medicines. It is also an important antioxidant and immune enhancer. For congestive heart failure, arrhythmias, sinus tachycardia, premature beats, hypertension and cancer adjuvant therapy for acute and chronic viral hepatitis and subacute hepatic necrosis comprehensive treatment. In addition, it is also tested in primary and secondary aldosteronism, cerebrovascular disorders and hemorrhagic shock. during the application, user may appear nausea, upset stomach, loss of appetite and other phenomena, urticaria, and a transient palpitations occasionally appear.
2. Cardiovascular medicine.
3. It can be widely used in food, cosmetics, dietary supplements and other industries. Coenzyme drugs, is also an important antioxidant and immune enhancer.
4. It can activate human cells and cellular energy nutrition, it can improve human immunity, enhance anti-oxidation, anti-aging and enhance human activity. In addition, recent studies indicate that the product also has anti-tumor effects, for advanced metastatic cancer have a certain effect in clinical, have a significant effect in the prevention of coronary heart disease, alleviate periodontitis, treatment of duodenal and gastric ulcer, strengthen the immune system function and relieve angina . Because Ubidecarenone is effective and without side effects. It is used in pharmaceuticals, cosmetics, food additives and other industries. Antibacterial, antioxidant ubiquinone is also known as coenzyme Q10 it is a powerful antioxidant that is naturally found in the cells. It acts as a free radical neutraliser. antioxidant, cardiovascular agent Antibacterial and antioxidant for preventing and treating cancer. A mitochondrial transporter chain component Coenzyme Q10 (CoQ10) is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies, and other chronic diseases.[Cayman Chemical]