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Chlorambucil

Chlorambucil structure

CAS No:
305-03-3
Formula:
C14H19Cl2NO2
Chemical Name:
Chlorambucil
Synonyms:
Benzenebutanoic acid,4-[bis(2-chloroethyl)amino]-;Butyric acid,4-[p-[bis(2-chloroethyl)amino]phenyl]-;4-[Bis(2-chloroethyl)amino]benzenebutanoic acid;CB 1348;4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid;γ-[p-Bis(2-chloroethyl)aminophenyl]butyric acid;Chlorambucil;Chloraminophene;Chlorobutine;γ-[p-Di(2-chloroethyl)aminophenyl]butyric acid;Leukeran;Chlorbutin;Amboclorin;NSC 3088;Ambochlorin;Linfolizin;Ecloril;Linfolysin;Lympholysin;Leukeran Tablets;NCI 3088;4-[4-[Bis(2-chloroethyl)amino]phenyl]butanoic acid
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

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Description

Chlorambucil is an alkylating agent with antitumor activity.

Chlorambucil Basic Attributes

Molecular Weight：

304.21

Exact Mass：

304.21

EC Number：

206-162-0

HScode：

2922499990

Characteristics

PSA：

40.5

XLogP3：

3.9

Appearance：

Chlorambucil appears as white to pale beige crystalline or granular powder with a slight odor. Melting point 65-69°C.

Density：

1.2±0.1 g/cm3

Melting Point：

64-66 °C

Boiling Point：

460.1±40.0 °C at 760 mmHg

Flash Point：

232.1±27.3 °C

Refractive Index：

1.570

Water Solubility：

H2O: <0.01 g/100 mL at 22 ºC

Storage Conditions：

2-8°C

Vapor Pressure：

9.30X10-7 mm Hg at 25 deg C (est)

Toxicity：

Oral-rat LD50: 76 mg/kg; Oral-Mouse LD50: 101 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides and chloride fumes

Odor：

Slight odor

PKA：

5.75None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

45-25-36/37/38

safety instructions：

53-26-45

RTECS Number：

ES7525000

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

Stability/Shelf Life：

Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

Missing Phrase - N15.00950417-P201-P280-P305 + P351 + P338-P308 + P313

Hazard Statements：

H301-H315-H319-H335-H350

Toxicity

Toxicity class：

highly toxic

Chlorambucil Use and Manufacturing

Methods of Manufacturing

From 4-p-aminophenylbutyric acid by hydrogen chloride methanol solution esterification, acetic acid and ethylene oxide hydroxyethylation, phosphorus oxychloride chlorination, concentrated hydrochloric acid derived.

Uses

tranquilization aid

Computed Properties

Molecular Weight:304.2
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:303.0792842
Monoisotopic Mass:303.0792842
Topological Polar Surface Area:40.5
Heavy Atom Count:19
Complexity:250
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Phosphorus oxychloride

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Chlorambucil Tablets
Ingredients	The main ingredient of this product is chlorambucil.
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Specifications	2mg

Chlorambucil Tablets
Ingredients	The main ingredient of this product is chlorambucil.

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Registered Holders

BIOPHORE INDIA PHARMACEUTICALS PVT LTD

United States
Active
BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.

European Union
Active

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CAS No.: 305-03-3

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