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Pargyline hydrochloride

Pargyline hydrochloride structure

CAS No:
306-07-0
Formula:
C11H13N.ClH
Chemical Name:
Pargyline hydrochloride
Synonyms:
Benzenemethanamine,N-methyl-N-2-propyn-1-yl-,hydrochloride (1:1);Benzylamine,N-methyl-N-2-propynyl-,hydrochloride;Benzenemethanamine,N-methyl-N-2-propynyl-,hydrochloride;N-Benzyl-N-methyl-2-propynylamine hydrochloride;Eutonyl;N-Methyl-N-(2-propynyl)benzylamine hydrochloride;Pargyline hydrochloride;Methylbenzylpropynylamine hydrochloride;Eutonyl-ten;NSC 43798;MO 911;A 19120;8055-70-7
Categories:
Organic Chemistry > Amides

Description

Pargyline hydrochloride is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.

Pargyline Hydrochloride is the hydrochloride salt form of pargyline, a monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.|A monoamine oxidase inhibitor with antihypertensive properties.

Pargyline hydrochloride Basic Attributes

Molecular Weight：

195.69

Exact Mass：

195.081482

EC Number：

206-175-1

UNII：

W70V6I2OMY

NSC Number：

757264|43798

DSSTox ID：

DTXSID1044647

NCI Thesaurus Code：

C66323

Characteristics

PSA：

3.2

Melting Point：

154-155 °C

Flash Point：

83.9ºC

Storage Conditions：

−20°C

Toxicity：

Oral-rat LD50: 142 mg/kg; Oral-Mouse LD50; 680 mg/kg

Flammability characteristics：

Combustible; burning produces toxic nitrogen oxides and hydrogen chloride fumes; drug side effects: affects mental state; affects liquid absorption

Collision Cross Section：

134.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

22-24/25

RTECS Number：

DP6650000

Marks：

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H301

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)

MeSH Entry Terms：

Hydrochloride, Pargyline

Pargyline hydrochloride Use and Manufacturing

Uses

Antihypertensor;Monoamine oxidase inhibitor

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:195.69
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:195.0814771
Monoisotopic Mass:195.0814771
Topological Polar Surface Area:3.2
Heavy Atom Count:13
Complexity:159
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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CAS No.: 306-07-0

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