Propargyl bromide

118.96

118.96

605309

203-447-1

F3H7ZXK9ZU

8801

2345

DTXSID3042340

Liquid|Colorless, crystalline

2903399090

0

1.39 (est)

White to off-white Powder

1.579 g/cm³ @ Temp: 19 °C

107-108 °C @ Solvent: Hexane

88-90 °C

65 °F

n 20/D 1.494

Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.

Refrigerator

1.08X10+2 mm Hg at 25 deg C (est)

6.87 (Air = 1)

Oral-rat LDL0: 53 mg/kg

Flammable; heat decomposes toxic bromide gas

When /propargyl bromide/ is heated under confinement ... the material may detonate.

Sharp odor

0.00 atm-m3/mole|Henry's Law constant = 1.13X10-3 atm-cu m/mol at 25 °C

Freezing point = -61.07 °C|/Propargyl bromide/ is an acetylenic compound which may be decomposed by mild shock.|Hydroxyl radical reaction rate constant = 5.6X10-12 cu cm/molecule-sec at 25 °C (est)

Highly flammable. Insoluble in water.

Halogenated Organic Compounds

Highly Flammable

3-BROMOPROPYNE is soluble in alcohol, ether, chloroform, carbon tetrachloride and carbon disulfide. It is highly flammable and a dangerous fire risk, sensitive to shock. It is used in organic syntheses, preparation of resins and perfume intermediates [Hawley]. There is a high danger of formation of explosive metal acetylides, when this compound comes in contact with copper, high-copper alloys, mercury, or silver.

615 °F (324 °C)

Lower flammable limit: 3.0%

II

3

UN 2345 3/PG 2

3

60-61-20/21-25-63-36/37/38-11-67-65-48/20

53-16-36/37/39-45-37/39-28A-26-62-36/37

UK4375000

F,T,C

Treasury is ventilated, low temperature and dry; stored and transported separately from oxidant

Highly Flammable/Toxic/Corrosive

Mix with air to form explosive mixture

When /propargyl bromide/ is diluted, with 20-30% by weight of toluene, its explosive properties are practically eliminated.

P210-P261-P281-P301 + P310-P305 + P351 + P338-P331

H225-H301-H304-H315-H319-H335-H336-H361d-H373

Dissolve in a combustible solvent. Scatter spray of solution into a furnace with afterburner and alkali scrubber.|SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

The aerated liquid may be ignited by pressure.|It can detonate when heated to 220 °C, by impact(especially when mixed with chloropicrin) or when heated while confined.|Can react vigorously with oxidizing materials.|There is a danger of explosion in contact with copper, high copper alloys, mercury or silver (arising from metal acetylide formation).

UN 2345

P210; P260; P280; P370 + P378; P403 + P235

This material detonates at 428F or more; ignites by impact. Emits highly toxic fumes of bromides when heated to decomposition. Reacts vigorously with oxidizing materials. Becomes shock-sensitive when mixed with chloropicrin. Unstable, avoid heat, flame, shock, and other chemicals (EPA, 1998)|Flammable - 3rd degree, Reactive - 4th degree

|Danger|H225 (92%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 50 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P310, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Wear special protective clothing and positive pressure self-contained breathing apparatus.|Personnel Protection: ... Wear appropriate chemical protective gloves, boots and goggles.

Fire and Explosion Hazards: Flammable liquid. Combustion may produce irritants and toxic gases. Closed containers may rupture violently when heated. May be decomposed by mild shock. Decomposes when heated; if diluted with toluene, its explosive properties are practically eliminated.

When /propargyl bromide/ is heated under confinement ... the material may detonate.

Fire Fighting Procedure: Use water spray, dry chemical, foam, or carbon dioxide. Use fine spray or fog to control fire by preventing its spread and absorbing some of its heat. Application of a water blanket may be effective for extinguishment. Use water spray to keep fire-exposed containers cool. Fight fire from protected location or maximum possible distance. Approach fire from upwind to avoid hazardous vapors and toxic decomposition.|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.

Absorb the spill with paper towels. ... Place in hood to evaporate material.|Spill or leak procedures: Eliminate all ignition sources. Stop or control the leak, if this can be done without undue risk. Use water spray to cool and disperse vapors, and protect personnel. Control runoff and isolate discharged material for proper disposal. Fire situations may require evacuation.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.|Personnel protection: Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. If contact with the material anticipated, wear appropriate chemical protective clothing.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 130: FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for 3-BROMO-1-PROPYNE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritating to skin, eyes, and respiratory system.|Irritation of skin and mucous membranes.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 4 - Materials that in themselves are readily capable of detonation or explosive decomposition or explosive reaction at normal temperatures and pressures.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Propargyl bromide is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 10 lbs.

highly toxic

LD50 Rabbit oral 168 mg/kg|LD50 Dog oral 913 mg/kg|LD50 Guinea pig oral 29 ug/kg /SRP: mg/kg/

3-Bromo-1-propyne's production and use as a chemical intermediate(1) may result in its release to the environment through various waste streams; its former production and use as a soil fumigant(1) may have resulted in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 1.1 and 5.3(2) indicate that 3-bromo-1-propyne is expected to have very high mobility in soil(SRC). Volatilization of 3-bromo-1-propyne from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.13X10-3 atm-cu m/mole(2). 3-Bromo-1-propyne is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 108 mm Hg(SRC), calculated using a water solubility of 1.49X10+4 mg/L(2) and the Henry's Law constant(2). Biodegradation in soil is not expected to compete with chemical degradation processes based on similar half-lives in sterile soil (0.37-11 days) and nonsterile soil (0.046-12 days)(2,3,4). It has been proposed that the alkylation of soil organic matter is the primary degradation process for 3-bromo-1-propyne in soil(2-4).|TERRESTRIAL FATE: The measured first-order degradation rate constants for 310 mg/kg 3-bromo-1-propyne in autoclaved Arlington sand loam, nonautoclaved Arlington sand loam, autoclaved Linne clay loam, and nonautoclaved Linne clay loam were 0.065, 0.056, 0.20, and 0.20 per day, respectively, which correspond to half-lives of 11, 12, 3.5, and 3.5 days, respectively(1). The measured first-order degradation rate constants for 20 mg/kg 3-bromo-1-propyne in sterile Arlington sandy loam, Carsitas loamy sand, and Linne clay loam were 0.18, 0.57, and 0.39 per day, respectively, which correspond to half-lives of 3.9, 1.2, and 1.8 days, respectively(2). Measured rate constants for this substance (20 mg/kg) in nonsterile Arlington sandy loam, Carsitas loamy sand, and Linne clay loam were 0.14, 0.46, and 0.48 per day, respectively, which correspond to half-lives of 5.0, 1.5, and 1.4 days, respectively(2). Half-lives determined from first-order degradation rate constants for 0.7 mg/kg 3-bromo-1-propyne in sterile Coachella fine sand, Arlington sandy loam, Chualar loam, and Florida muck were 2.4, 2.4, 1.0, and 0.37 days, respectively at an inital concentration of 0.7 mg/kg; 3.2, 4.6, 3.0, and 0.71 days, respectively at an initial concentration of 7 mg/kg; and 6.3, 6.9, 3.5, and 1.2 days, respectively at an initial concentration of 70 mg/kg(3). Half-lives determined from first-order degradation rate constants for 0.7 mg/kg propargyl bromide in non-sterile Coachella fine sand, Arlington sandy loam, Chualar loam, and Florida muck were 3.5, 0.39, 0.36, and 0.046 days, respectively at an inital concentration of 0.7 mg/kg; 4.1, 3.6, 2.8, and 0.43 days, respectively at an initial concentration of 7 mg/kg; and 8.7, 7.7, 4.6, and 1.1 days, respectively at an initial concentration of 70 mg/kg(3).|AQUATIC FATE: Based on a classification scheme(1), Koc values of 1.1 and 5.3(2), indicate that 3-bromo-1-propyne is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.13X10-3 atm-cu m/mole(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hours and 5 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 3(SRC), from a water solubility of 1.49X10+4 mg/L(2) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 3-Bromo-1-propyne is expected to undergo hydrolysis based on measured half-lives of 64 and 47 days at 22 and 25 °C, respectively(2,6). Biodegradation in water is not expected to compete with chemical degradation processes based on similar half-lives in sterile soil (0.37-11 days) and nonsterile soil (0.046-12 days)(2,6,7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-bromo-1-propyne, which has an estimated vapor pressure of 108 mm Hg at 25 °C(SRC), calculated from a water solubility of 1.49X10+4 mg/L(2) and a Henry's Law constant of 1.13X10-3 atm-cu m/mol(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 3-bromo-1-propyne is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 5.6X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Propargyl bromide does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 3-bromo-1-propyne with photochemically-produced hydroxyl radicals has been estimated as 5.6X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A hydrolysis half-life of 47 days at 25 °C was calculated for 3-bromo-1-propyne using a rate constant (not reported) determined from measurements at temperatures between 2 and 40 °C(2). A hydrolysis half-life of 64 days at 22 °C has also been measured for this substance(3). The hydrolysis products observed during this reaction were propargyl hydroxide and bromide ion(3). 3-Bromo-1-propyne does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).|The measured first-order degradation rate constants for 310 mg/kg propargyl bromide in autoclaved Arlington sand loam and Linne clay loam were 0.065 and 0.20 per day, respectively, which correspond to half-lives of 11 and 3.5 days, respectively(1). The measured first-order degradation rate constants for 20 mg/kg 3-bromo-1-propyne in sterile Arlington sandy loam, Carsitas loamy sand, and Linne clay loam were 0.18, 0.57, and 0.39 per day, respectively, which correspond to half-lives of 3.9, 1.2, and 1.8 days, respectively(2). Half-lives determined from first-order degradation rate constants for 0.7 mg/kg 3-bromo-1-propyne in sterile Coachella fine sand, Arlington sandy loam, Chualar loam, and Florida muck were 2.4, 2.4, 1.0, and 0.37 days, respectively at an inital concentration of 0.7 mg/kg; 3.2, 4.6, 3.0, and 0.71 days, respectively at an initial concentration of 7 mg/kg; and 6.3, 6.9, 3.5, and 1.2 days, respectively at an initial concentration of 70 mg/kg(3). It has been proposed that the primary degradation process for 3-bromo-1-propyne in soil is the alkylation of soil organic matter(1-3).

An estimated BCF of 3 was calculated for 3-bromo-1-propyne(SRC), using a water solubility of 1.49X10+4 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Koc values of 1.1 and 5.3 were determined for 3-bromo-1-propyne in Linne clay loam (Kd = 0.033, 2.99% organic matter) and Arlington sandy loam (Kd = 0.049, 0.93% organic matter), respectively(1). According to a classification scheme(2), these Koc values suggest that 3-bromo-1-propyne is expected to have very high mobility in soil.

The Henry's Law constant for 3-bromo-1-propyne is 1.13X10-3 atm-cu m/mole(1). This Henry's Law constant indicates that 3-bromo-1-propyne is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). 3-Bromo-1-propyne's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 3-Bromo-1-propyne is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 108 mm Hg(SRC), calculated using a water solubility of 1.49X10+4 mg/L(2) and its Henry's Law constant(2).

DRINKING WATER: 3-Bromo-1-propyne was listed among chemicals that have been detected in drinking water collected from Europe and the United States(1). However, neither concentration data nor frequency of detection were reported(1).

Occupational exposure to 3-bromo-1-propyne may occur through inhalation and dermal contact with this compound at workplaces where 3-bromo-1-propyne is produced or used. (SRC)

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc. (See all compounds classified as Fungicides, Industrial.)

This material is very toxic via the oral route. If inhaled, may be harmful; contact may cause burns to skin and eyes. (EPA, 1998)

Warning: Propargyl bromide is very toxic via the oral route, has corrosive effects, causes burns to skin and eyes, and is a strong lacrimating agent. Signs and Symptoms of Propargyl Bromide Exposure: Signs and symptoms of acute exposure to propargyl bromide may include irritation or burning of eyes, nose, throat, respiratory tract with potential chemical pneumonitis or pulmonary edema, esophageal, GI tract, and skin irritations or burns. Kidney and hepatic injury has occurred in animals following exposure to propargyl bromide. Emergency Life-Support Procedures: Acute exposure to propargyl bromide may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to propargyl bromide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to propargyl bromide. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas three times with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures. 3. DO NOT induce vomiting. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should not be given if victims are not conscious and alert. 7. Transport to a health care facility. (EPA, 1998)

/SIGNS AND SYMPTOMS/ Symptomatology: 1. A. Inhalation, high vapor concn: gasping, refusal to breathe, coughing, substernal pain, and extreme respiratory distress at vapor concn over 1500 ppm. Irritation of eyes and upper respiratory mucosa appears promptly after exposure to concentrated vapors. Lacrimation and headache are prominent. Coma may occur rapidly. B. Inhalation, low vapor concentrations: Central nervous depression and moderate irritation of respiratory system. Headache is frequent. /Dichloropropenes/|/SIGNS AND SYMPTOMS/ Symptomatology: 2. Dermal: Severe skin irritation with marked inflammatory response of epidermis and underlying tissues. 3. Oral: Acute gastrointestinal distress with pulmonary congestion and edema. Central nervous depression, perhaps even in the absence of impaired oxygen uptake. 4. By any route, possible late injuries to liver, kidneys and heart. 5. After inhalation exposures, malaise, headache, chest and abdominal discomfort and irritability have been reported to persist for several years. /Dichloropropenes/|/SIGNS AND SYMPTOMS/ Vapors and liquid are corrosive toward skin, eyes, and mucous membranes.|/Propargyl bromide/ vapors are very toxic.

3-bromopropyne

1-Propyne, 3-bromo-: ACTIVE|... A process for preparing propargyl phenols /was presented/. ... A polyhydric phenolic material is reacted with propargyl bromide in aqueous sodium hydroxide solution. The reaction occurs at the interface between the aqueous basic solution of the phenolic material and the propargyl bromide which is insoluble in water.|In search of new tuberculostatic agents, imidazoline-2-thiol and some of its derivatives were reacted with propargyl bromide, and the compounds obtained were reacted with some arylsulfonyl chlorides, aromatic aldehydes, isocyanates and isothiocyanates. Fourteen resultant compounds were characterized and shown to display varied tuberculostatic activity when tested against Mycobacterium tbc 607 and H37Rv strains.

Fire Hazards -> Flammable - 3rd degree, Reactive - 4th degree