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Guanosine

Guanosine structure

CAS No:
118-00-3
Formula:
C10H13N5O5
Chemical Name:
Guanosine
Synonyms:
Guanosine;Guanine,9-β-D-ribofuranosyl-;Inosine,2-amino-;Vernine;β-D-Ribofuranoside,guanine-9;6H-Purin-6-one,2-amino-1,9-dihydro-9-β-D-ribofuranosyl-;2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one;Guanine ribonucleoside;NSC 19994;DL-Guanosine;7: PN: WO2013104540 PAGE: 124 claimed sequence;85-30-3;484-80-0;685891-87-6;1022900-70-4
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

White, crystalline powder; odorless; mild saline taste. Very slightly soluble in cold water; soluble in boiling water, dilute mineral acids, hot acetic acid, and dilute bases; insoluble in alcohol, ether, chloroform, and benzene.ChEBI: A purine nucleoside in which guanine is attached to ribofuranose via a beta-N9-glycosidic bond. A NUCLEOSIDE present in DNA and RNA and consisting of guanine linked to D-ribose via a β-glycosidic bond.Guanosine is a purine nucleoside, in which the guanine a

Solid

Guanosine is a purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond. It has a role as a fundamental metabolite. It is a purines D-ribonucleoside and a member of guanosines. It derives from a guanine.|Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and GTP (guanosine triphosphate) which are factors in signal transduction pathways.|Guanosine is a purine nucleoside formed from a beta-N9-glycosidic bond between guanine and a ribose ring and is essential for metabolism.|A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)

Guanosine Basic Attributes

Molecular Weight：

283.24

Exact Mass：

283.24

BRN：

625911

EC Number：

204-227-8

UNII：

12133JR80S

DSSTox ID：

DTXSID30747870

NCI Thesaurus Code：

C533

HScode：

29349990

Characteristics

PSA：

155

XLogP3：

-2.7

Appearance：

White to light yellow Powder

Density：

1.3790 (rough estimate)

Melting Point：

239 °C (decomp)

Boiling Point：

425.8°C (rough estimate)

Flash Point：

423.1ºC

Refractive Index：

-76 ° (C=1, 1mol/L NaOH)

Water Solubility：

H2O: 0.75 g/L (25 ºC);0.1 M NaOH: 0.1 g/mL, clear, slightly yellow

Storage Conditions：

Store at RT.

Vapor Pressure：

2.44E-25mmHg at 25°C

Specific rotation：

-62 º (c=3, in 0.1 N NaOH)

Collision Cross Section：

174.6 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|165.02 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|177.25 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|164.38 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|160 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|163.4 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|174.3 Å² [M+K]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|174.9 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|162.1 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|163 Å² [M-H]-

Safety Information

Packing level：

Ⅲ

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

45-24/25-23

RTECS Number：

MF8750000

Marks：

T,Xi

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P264, P270, P301+P310, P321, P330, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (99.08%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 119 companies from 5 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

Guanosine

Guanosine Use and Manufacturing

Uses

A constituent of nucleic acids.

Manufacturing Info：

Guanosine: ACTIVE

Use Classification：

Cosmetics -> Opacifying; Skin conditioning

Computed Properties

Molecular Weight:283.24
XLogP3:-1.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:283.09166853
Monoisotopic Mass:283.09166853
Topological Polar Surface Area:155
Heavy Atom Count:20
Complexity:446
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Guanosine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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