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4-Hydroxyestrone

4-Hydroxyestrone structure

CAS No:
3131-23-5
Formula:
C18H22O3
Chemical Name:
4-Hydroxyestrone
Synonyms:
Estra-1,3,5(10)-trien-17-one,3,4-dihydroxy-;3,4-Dihydroxyestra-1,3,5(10)-trien-17-one;4-Hydroxyestrone;3,4-Dihydroxy-1,3,5(10)-estratrien-17-one
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Pale Yellow Solid

4-hydroxyestrone is a 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4. It has a role as an estrogen, a human urinary metabolite and a carcinogenic agent. It is a 4-hydroxy steroid, a 17-oxo steroid, a 3-hydroxy steroid, a catechol and a phenolic steroid. It derives from an estrone.|4-Hydroxyestrone is a metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 4 by cytochrome P450 (CYP) family enzymes, with potential carcinogenic activity. The mechanism of action for the tumor promoting activity of 4-hydroxyestrone is not known but this metabolic product has increased estrogenic activity compared to the parent compound. Additionally, oxidation of 4-hydroxyestrone generates compounds with free radicals that are capable of removing purines from DNA, which can cause mutagenesis and can lead to tumorigenesis.

4-Hydroxyestrone Basic Attributes

Molecular Weight：

286.371

Exact Mass：

286.37

UNII：

3MN57C55S2

NCI Thesaurus Code：

C114469

Characteristics

PSA：

57.5

XLogP3：

3.52300

Density：

1.241g/cm3

Melting Point：

260-265 °C @ Solvent: Benzene, Methanol

Boiling Point：

468.2ºC at 760mmHg

Flash Point：

251.1ºC

Refractive Index：

1.61

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

KG7749500

Drug Information

Metabolism/Metabolites：

4-hydroxyestrone has known human metabolites that include 4-methoxyestrone and Estrone 4-O-glucuronide.

MeSH Entry Terms：

3,4-dihydroxy-1,3,5(10)-estratrien-17-one

4-Hydroxyestrone Use and Manufacturing

A metabolite of Estradiol

Computed Properties

Molecular Weight:286.4
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Exact Mass:286.15689456
Monoisotopic Mass:286.15689456
Topological Polar Surface Area:57.5
Heavy Atom Count:21
Complexity:448
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Hydroxyestrone

Hefei Heyu Chemical New Materials Co., Ltd Contact Supplier

CN
4 YRS

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4-Hydroxy Estrone

CAS No.: 3131-23-5

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Cuicheng Biomedical Technology Contact Supplier

CN
1 YR

Business licensed Certified factory

Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

4-Hydroxyestrone

Unit Price: $5000-6000 /G FOB

CAS No.: 3131-23-5

Grade: Industrial Grade

Content: 98%

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