 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > 4-Hydroxyestrone for Sale > 4-Hydroxyestrone

4-Hydroxyestrone

Name: 4-Hydroxyestrone
Brand: Cuicheng Bio
SKU: pr2606102246
Price: 5000 USD
Availability: InStock

Unit Price:

$5000-6000/G FOB

Get Latest Price 

CAS No.:

3131-23-5

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5 mg

Price valid (until):

2026-07-23

Contact Supplier

 Chat Now

Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

 Visit Store

Product Description
Seller Information

Description

4-Hydroxyestrone (4-OH E1) is a naturally occurring catechol estrogen and a major Phase I metabolite of estrone and estradiol. Rather than serving as a primary signaling hormone, it is a metabolic breakdown product whose primary functions and clinical relevance revolve around cellular toxicity, DNA mutation risk, and neurological defense.

Primary Biological and Pharmacological Functions

DNA Mutagenesis and Genotoxicity: 4-Hydroxyestrone is highly chemically reactive. If Phase II detoxification pathways (like methylation) are sluggish, it oxidizes into electrophilic 3,4-semiquinones and quinones. These reactive molecules directly bind to DNA, forming depurinating DNA adducts that cause genetic mutations.
Oncogenic Tissue Growth Support: Unlike some weaker estrogen metabolites, 4-Hydroxyestrone retains persistent estrogenic activity. It stimulates estrogen receptors to promote cell proliferation, making it a critical biomarker and risk factor for estrogen-sensitive cancers, particularly breast and uterine cancers.
Potent Neuroprotection: In the central nervous system, where it acts as a "neuroestrogen," 4-Hydroxyestrone functions as a powerful antioxidant. Biochemical testing shows it has a stronger protective profile against oxidative neurotoxicity than 17β-estradiol, actively guarding hippocampal brain cells from oxidative damage.

Basic Info

Product Name:

4-Hydroxyestrone

Other Name:

Estra-1,3,5(10)-trien-17-one,3,4-dihydroxy-;3,4-Dihydroxyestra-1,3,5(10)-trien-17-one;4-Hydroxyestrone;3,4-Dihydroxy-1,3,5(10)-estratrien-17-one

CAS No.:

3131-23-5

Molecular Formula:

C18H22O3

InChIKeys:

InChIKey=XQZVQQZZOVBNLU-QDTBLXIISA-N

Molecular Weight:

286.371

Exact Mass:

286.37

UNII:

3MN57C55S2

NCI Thesaurus Code:

C114469

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

57.5

XLogP3:

3.52300

Density:

1.241g/cm3

Melting Point:

260-265 °C @ Solvent: Benzene, Methanol

Boiling Point:

468.2ºC at 760mmHg

Flash Point:

251.1ºC

Refractive Index:

1.61

See More 4-Hydroxyestrone Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4-Hydroxyestrone Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
4-Hydroxy Estrone	/		Hefei Heyu Chemical New Materials Co., Ltd	Inquiry

4-Hydroxyestrone

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

Related Searches