5,6-Dihydroxyindole
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5,6-Dihydroxyindole
structure -
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CAS No:
3131-52-0
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Formula:
C8H7NO2
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Chemical Name:
5,6-Dihydroxyindole
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Synonyms:
1H-Indole-5,6-diol;Indole-5,6-diol;Dopamine lutine;5,6-Dihydroxyindole;Indolylquinol
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CAS No:
Description
Solid
Solid
5,6-dihydroxyindole is a dihydroxyindole. It has a role as a mouse metabolite.
Characteristics
56.2
1.3
Solid
1.5±0.1 g/cm3
140 °C (decomp)
411.2°C at 760 mmHg
202.5±23.2 °C
1.802
Safety Information
22-41-51/53
22-26-36/37/39-61
NL7858000
Xn,N
P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P330, P391, P501
H302
|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P305+P351+P338, P310, P330, P391, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE. (See all compounds classified as Catechol O-Methyltransferase Inhibitors.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Dihyroxy-1H-indole has known human metabolites that include Dihyroxy-1H-indole glucuronide I.
5,6-dihydroxyindole
5,6-Dihydroxyindole Use and Manufacturing
Sodium chloride was added to the melanin precursor solution (composed mainly of Dopachrome) obtained in the step 5 to give a final concentration of 2.5percent. The resulting mixture was allowed to stand at room temperature for 45 minutes, whereby conversion of Dopachrome to 5, 6-dihydroxyindole was accelerated compared with the precursor solution free of sodium chloride. Addition of a sodium ascorbate solution instead of sodium chloride caused a marked amount of 5, 6-dihydroxyindole (ratio of 5, 6-dihydroxyindole present in the melanin precursor solution: 90percent).
Cosmetics -> Hair dyeing
Computed Properties
Molecular Weight:149.15
XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Exact Mass:149.047678466
Monoisotopic Mass:149.047678466
Topological Polar Surface Area:56.2
Heavy Atom Count:11
Complexity:151
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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