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Acetylcholine chloride

Acetylcholine chloride structure

CAS No:
60-31-1
Formula:
C7H16NO2.Cl
Chemical Name:
Acetylcholine chloride
Synonyms:
Ethanaminium,2-(acetyloxy)-N,N,N-trimethyl-,chloride (1:1);Choline acetate (ester),chloride;Ethanaminium,2-(acetyloxy)-N,N,N-trimethyl-,chloride;Acecoline;2-Acetoxyethyltrimethylammonium chloride;Acetylcholine chloride;ACh chloride;Arterocoline;(2-Hydroxyethyl)trimethylammonium chloride acetate;Ovisot;Acetylcholinium chloride;O-Acetylcholine chloride;Trimethyl(2-acetoxyethyl)ammonium chloride;Acecholin;Miochol;1784-29-8;70623-44-8;2028303-10-6
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Acetylcholine is a neurotransmitter that can induce the opening of calcium channels. Target: Calcium Channel; nAChR; mAChRAcetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthal

Acetylcholine chloride is the chloride salt of acetylcholine, and a parasympatomimetic drug. It contains an acetylcholine.|Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mimics the parasympathomimetic effect of the endogenous compound acetylcholine. Administered as an ophthalmic solution, this drug stimulates the cholinoceptors in the sphincter muscle of the iris, causing the pupil to constrict. (NCI05)|A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

Acetylcholine chloride Basic Attributes

Molecular Weight：

181.66

Exact Mass：

181.086960

BRN：

3571875

EC Number：

200-468-8

UNII：

AF73293C2R

NSC Number：

755845

DSSTox ID：

DTXSID5048978

NCI Thesaurus Code：

C47382

HScode：

29379000

Characteristics

PSA：

26.3

Appearance：

White Crystalline Powder

Density：

1.27 g/cm³

Melting Point：

150 °C

Water Solubility：

H2O: 0.1 g/mL, clear, colorless

Storage Conditions：

0-6°C

Toxicity：

Oral-Rat LD50: 2500 mg/kg; Oral-Mouse LD50: 3000 mg/kg

Flammability characteristics：

Flammable; decomposes by heating to release toxic nitrogen oxides and chloride fumes

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39-36

RTECS Number：

FZ9800000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 161 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs that bind to and activate cholinergic receptors. (See all compounds classified as Cholinergic Agonists.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

2-(Acetyloxy)-N,N,N-trimethylethanaminium

Acetylcholine chloride Use and Manufacturing

Methods of Manufacturing

It takes chloroethanol and trimethylamine aqueous solution as the starting materials to react, then acylates with acetic anhydride, and finally refines it.

Uses

A cholinergic neurotransmitter that can induce the opening of calcium channels

Manufacturing Info：

Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1): ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:181.66
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:181.0869564
Monoisotopic Mass:181.0869564
Topological Polar Surface Area:26.3
Heavy Atom Count:11
Complexity:115
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Ethanol

Acetic acid

Choline chloride

Trimethylamine

Drug Function and Efficacy

Acetylcholine is a neurotransmitter essential for memory, learning, and muscle activation at neuromuscular junctions

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

NEUROBALANCE PRO- adrenocorticotrophin, gaba, glutamic acid, norepinephrine, acetylcholine chloride, adrenalinum, l-dopa, serotonin (hydrochloride), thyroidinum (suis), anacardium orientale, baryta carbonica, calcarea carbonica, stramonium_liquid
Manufacturer	The Wellness Center for Reseach and Education, Inc.

Registered Holders

東京化成工業株式会社

Japan
Active
SIGMA F AND D DIV LTD

United States
Inactive
Siegfried Ltd

United States
Inactive

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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