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5-Aminofluorescein

5-Aminofluorescein structure

CAS No:
3326-34-9
Formula:
C20H13NO5
Chemical Name:
5-Aminofluorescein
Synonyms:
Spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one,5-amino-3′,6′-dihydroxy-;Fluorescein,5-amino-;5-Amino-3′,6′-dihydroxyspiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one;4-Aminofluorescein;Fluorescein amine isomer 1;Fluoresceinamine-I;5-Aminofluorescein;1169-63-7;392315-52-5;720671-84-1;861856-92-0;189245-39-4;880014-77-7;929976-68-1;933980-38-2;1005309-82-9;1019184-43-0;1034887-98-3;1065108-93-1;1174859-25-6;1185291-77-3;1188262-96-5;887355-15-9
Categories:
Chemical Reagents > Organic Reagents

Description

5-Aminofluorescein (5-AF) is a new fluorescence marker, covalently bound to human serum albumin (AFL-HSA) [1]5-aminofluorescein is a pH-sensitive biomaterial, is the targeted prodrug for synthesis of FA-FITC-Arg-PTX and FA-5AF- Glu-PTX..

5-aminofluorescein is a primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. It derives from a fluorescein (lactone form).

5-Aminofluorescein Basic Attributes

Molecular Weight：

347.32

Exact Mass：

347.32

EC Number：

222-043-6

DSSTox ID：

DTXSID0062979

HScode：

2921199090

Characteristics

PSA：

102

XLogP3：

2.7

Appearance：

red-brown powder

Density：

1.6±0.1 g/cm3

Melting Point：

223 °C (dec.)(lit.)

Boiling Point：

695.3°C at 760 mmHg

Flash Point：

374.3±31.5 °C

Refractive Index：

1.820

Water Solubility：

soluble in water (partly), methanol (10 mg/ml), and acetone.

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

Marks：

Stability/Shelf Life：

Light and Moisture Sensitive

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (98.81%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 84 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-aminofluorescein

5-Aminofluorescein Use and Manufacturing

Uses

Fluorescent labeling reagent for proteins.Used in the fluorescent antibody technique for rapid identification of pathogens

Manufacturing Info：

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy-: ACTIVE

Computed Properties

Molecular Weight:347.3
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Exact Mass:347.07937252
Monoisotopic Mass:347.07937252
Topological Polar Surface Area:102
Heavy Atom Count:26
Complexity:557
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Resorcinol

Disodium sulfide

Sodium hydrosulfide

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