5'-DEOXYTHYMIDINE
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5'-DEOXYTHYMIDINE
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CAS No:
3458-14-8
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Formula:
C10H14N2O4
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Chemical Name:
5'-DEOXYTHYMIDINE
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Synonyms:
5'-DEOXYTHYMIDINE;2',5'-dideoxythymidine;1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-methyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
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CAS No:
5'-DEOXYTHYMIDINE Use and Manufacturing
The pyrimidine thymidine consists of thymine combined with deoxyribose. Prior to polymerization into DNA, thymidine must be phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety. 5'-Deoxythymidine is a form of thymidine in which the hydroxyl group on carbon 5 of ribose has been replaced with hydrogen. As a result, this compound cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. 5'-Deoxythymidine is readily imported by cellular nucleoside importers and competitively inhibits the influx of thymidine. It demonstrates antibacterial activity against B. subtilis and S. aureus.[Cayman Chemical]
Computed Properties
Molecular Weight:226.23
XLogP3:-0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:226.09535693
Monoisotopic Mass:226.09535693
Topological Polar Surface Area:78.9
Heavy Atom Count:16
Complexity:366
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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