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Neomycin B

Neomycin B structure

CAS No:
119-04-0
Formula:
C23H46N6O13
Chemical Name:
Neomycin B
Synonyms:
D-Streptamine,O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-;Neomycin B;D-Streptamine,O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-;O-2,6-Diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine;Actilin;Actiline;Framycetin;Enterfram;Framidal;Framycin;Framygen;Francetin;Fraquinol;Antibiotic 10676;Dekamycin III;Fradiomycin B;Leo Red Dry Cow;Antibiotique EF 185;1393-86-8;11025-81-3;880259-35-8
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Framycetin (Fradiomycin B; Neomycin B) is an aminoglycoside antibiotic. It inhibits hammerhead ribozyme with a Ki of 13.5 μM.

Neomycin B Basic Attributes

Molecular Weight：

614.64

Exact Mass：

614.64

EC Number：

204-292-2

DSSTox ID：

DTXSID2023359

Characteristics

PSA：

353.11000

XLogP3：

-9

Appearance：

liquid

Density：

1.61 g/cm3

Melting Point：

6 °C (sulfate form)

Boiling Point：

927.1ºC at 760 mmHg

Flash Point：

514.5ºC

Refractive Index：

1.6000 (estimate)

Water Solubility：

6.47e+01 g/L

Storage Conditions：

2-8°C

Vapor Pressure：

1.60X10-28 mm Hg at 25 deg C (est)

Safety Information

wgk germany：

hazard class code：

42/43-63-36/37/38

safety instructions：

26-36/37/39-45-36/37-23

Marks：

Stability/Shelf Life：

Hygroscopic. /Neomycin sulfate/

Precautionary statement(s)：

P201, P202, P260, P281, P308+P313, P314, P405, P501

Hazard Statements：

H361

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P321, P330, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Computed Properties

Molecular Weight:614.6
XLogP3:-9
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:19
Rotatable Bond Count:9
Exact Mass:614.31228554
Monoisotopic Mass:614.31228554
Topological Polar Surface Area:353
Heavy Atom Count:42
Complexity:872
Undefined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Neomycin sulfate