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Clidinium bromide

Clidinium bromide structure

CAS No:
3485-62-9
Formula:
C22H26NO3.Br
Chemical Name:
Clidinium bromide
Synonyms:
1-Azoniabicyclo[2.2.2]octane,3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-,bromide (1:1);Quinuclidinium,3-hydroxy-1-methyl-,bromide,benzilate;1-Azoniabicyclo[2.2.2]octane,3-[(hydroxydiphenylacetyl)oxy]-1-methyl-,bromide;3-Hydroxy-1-methylquinuclidinium bromide,benzilate;Ro 2-3773;3-(Benziloyloxy)-1-methylquinuclidinium bromide;Clidinium bromide;1-Methyl-3-(benziloyloxy)quinuclidinium bromide;Quarzan;Quarzan bromide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Clidinium bromide is an anticholinergic (specifically a muscarinic antagonist) drug, may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines.

Clidinium bromide is the bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. It has a role as a parasympatholytic, an antispasmodic drug and an anti-arrhythmia drug. It is a quaternary ammonium salt and an organic bromide salt. It contains a clidinium. It derives from a benzilic acid and a 3-quinuclidinol.

Clidinium bromide Basic Attributes

Molecular Weight：

432.351

Exact Mass：

431.109589

EC Number：

222-471-3

NSC Number：

756686

DSSTox ID：

DTXSID7022835

HScode：

2933990090

Characteristics

PSA：

46.53000

XLogP3：

-0.33270

Appearance：

White Crystalline Solid

Melting Point：

240.5 °C

Storage Conditions：

Keep tightly closed. Store in a cool dry place.

Collision Cross Section：

183.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

R22

safety instructions：

S36

RTECS Number：

VD6125000

Marks：

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (95.12%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

clidinium

Clidinium bromide Use and Manufacturing

Uses

An anticholinergic. Used as an antispasmodic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:432.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:431.10961
Monoisotopic Mass:431.10961
Topological Polar Surface Area:46.5
Heavy Atom Count:27
Complexity:482
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Clidinium bromide

CAS No.: 3485-62-9

Content: 99.00%

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