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    Home > Pharmaceutical Intermediates > Sleep Disorder Agents > 2,5-Dichlorobenzooxazole
    2,5-Dichlorobenzooxazole structure

    2,5-Dichlorobenzooxazole

    • CAS No:

      3621-81-6

    • Formula:

      C7H3Cl2NO

    • Synonyms:

      2,5-DICHLOROBENZOXAZOLE;2,5-Dichlorobenzooxazole;Benzoxazole,2,5-dichloro-;2,5-dichlorobenzo[d]oxazole;2,5-Dichlorobenzooxazole(Forsuvorexant);2,5-dichloro-1,3-benzoxazole(SALTDATA:FREE);Benzoxazole,2,5-dichloro-(6CI,7CI,8CI,9CI)

    • China Export:

      From 2018.11 to 2019.11, total export volume of 2,5-Dichlorobenzooxazole from China was 64,534,318KG while total export value was $1,953,812,763. The biggest proportion of exporting volume in the last 12 months was 11.30% in 2019.03.

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    Basic Attributes

    • 3621-81-6

    • C7H3Cl2NO

    • 188.007

    • 186.959167

    • 26 A^2

    • 3.8

    • JOXBFDPBVQGJOJ-UHFFFAOYSA-N

    • 2

    • 0

    • 0.00

    • 0

    Characteristics

    • 1.5±0.1 g/cm3

    • 44-46 °C

    • 100.7±19.8 °C

    • 1.636

    Safety Information

    • 2934999090

    Production Methods

    Thionyl chloride (885 g, 7.5 mol)And N, N-dimethylformamide (270 ml) were added to a solution of 5-chloro-2-mercaptobenzoxazole (540 g, 2.903 mol) in dichloromethane (5 L) at 5-10 ° C.Stirred until a clear solution was formed and the reaction solution was stirred at room temperature for 4 hours.After completion of the reaction, the reaction solution was poured into 4 L of ice water, neutralized to neutral with sodium bicarbonate in 1 hour, and extracted with dichloromethane (2.5 L * 2).The organic layer was washed with brine, dried over sodium sulfate and dried to give the crude product. The crude product was washed with n-hexane (2 L * 2) at -20 ° C, filtered and dried to give yellow liquid 2, 5-dichlorobenzo (496.8 g, 91.0percent).Thionyl Chloride (540 mL) and Dimethyl formamide (270 mL) were added to a stirred mixture of 5-Chloro-1, 3-benzoxazole-2-thiol (540 g, 2.903 moles) and dichloromethane (5 liter) at 5-10° C. and stirred till clear solution was observed.

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    Material and Products

    China 2,5-Dichlorobenzooxazole Export Data

    Data referenced from General Administration of Customs,P.R.China

    2018.11-2019.11 China - America  2,5-Dichlorobenzooxazole Export Data

    From 2018.11 to 2019.11, total export volume of 2,5-Dichlorobenzooxazole from China to America was 7,780,901KG while total export value was $316,380,773. The biggest proportion of exporting volume in the last 12 months was 14.00% in 2019.01.

    2018.11-2019.11 China 2,5-Dichlorobenzooxazole Export Data

    From 2018.11 to 2019.11, total export volume of 2,5-Dichlorobenzooxazole from China was 64,534,318KG while total export value was $1,953,812,763. The biggest proportion of exporting volume in the last 12 months was 11.30% in 2019.03.

    2018.11-2019.11 TOP10 Purchasing Countries' Export Data of Chinese 2,5-Dichlorobenzooxazole

    From 2018.11 to 2019.11, China has exported 2,5-Dichlorobenzooxazole to 122 countries in total. Country ranks by import volume from high to low is India, America, Brazil, Korea, Japan, Indonesia, Russia, Italy, Vietnam, Germany. The highest export volume was China to India, accounting for 15.49% of the total volume of China.

    Check Export Data for More Purchasing Countries

    Purchasing Country Export Volume(KG) Export Percentage Export Value($)

    India

    18,470,088

    15.49%

    284,654,978

    America

    7,780,901

    6.52%

    316,380,773

    Brazil

    3,482,706

    2.92%

    56,330,619

    Korea

    3,279,208

    2.75%

    118,103,066

    Japan

    2,776,083

    2.33%

    104,179,065

    Indonesia

    2,652,708

    2.22%

    20,390,824

    Russia

    2,523,632

    2.12%

    71,402,429

    Italy

    1,949,908

    1.64%

    84,261,295

    Vietnam

    1,535,844

    1.29%

    30,876,165

    Germany

    1,414,521

    1.19%

    66,834,261

    Netherlands

    1,407,723

    1.18%

    40,043,364

    Taiwan

    1,336,285

    1.12%

    20,935,258

    Belgium

    1,300,937

    1.09%

    43,926,617

    Mexico

    1,203,788

    1.01%

    45,215,734

    Pakistan

    1,101,382

    0.92%

    39,507,765

    Iran

    1,044,291

    0.88%

    28,504,479

    Turkey

    905,770

    0.76%

    27,893,056

    Singapore

    780,141

    0.65%

    50,171,634

    Thailand

    719,956

    0.60%

    8,501,101

    Australia

    607,935

    0.51%

    14,879,125

    Israel

    588,856

    0.49%

    17,159,090

    South Africa

    575,310

    0.48%

    11,039,850

    United Kingdom

    501,238

    0.42%

    39,994,256

    Malaysia

    492,812

    0.41%

    5,439,297

    Spain

    446,770

    0.37%

    28,670,245

    United Arab Emirates

    304,282

    0.26%

    3,897,959

    Canada

    302,332

    0.25%

    21,196,696

    Colombia

    267,830

    0.22%

    8,161,669

    Poland

    267,574

    0.22%

    13,242,033

    Slovenia

    248,588

    0.21%

    18,698,953

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