Tolperisone hydrochloride
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Tolperisone hydrochloride
structure -
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CAS No:
3644-61-9
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Formula:
C16H23NO.ClH
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Chemical Name:
Tolperisone hydrochloride
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Synonyms:
1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-,hydrochloride (1:1);Propiophenone,2,4′-dimethyl-3-piperidino-,hydrochloride;1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-,hydrochloride;Mydocalm;1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride;Tolperisone hydrochloride;Muscalm;Midocalm;Tolisartine;N 553;Isocalm;Besnoline;Kineorl;Naismeritin;Minacalm;Atmosgen;Metosomin;Menopatol;Abbsa;Arantoick;2,4′-Dimethyl-3-piperidinopropiophenone hydrochloride;Tolpidol;Tolfree;Biocalm;84678-66-0
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Tolperisone is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia.
Tolperisone hydrochloride is an aromatic ketone.|A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)
Tolperisone hydrochloride Basic Attributes
281.82
281.154633
222-876-5
757872
DTXSID2045868
2933399090
Characteristics
20.3
4.03960
white
176-177 °C
373.9°C at 760 mmHg
134.4ºC
H2O: >20mg/mL
room temp
LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)
160.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
20/21/22-52/53-36/37/38
26-36-45-61-36/37-37/39
UH1575500
Xn,Xi
P280-P305 + P351 + P338
H302-H312-H319-H332
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 95 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)
Hydrochloride, Tolperisone
Computed Properties
Molecular Weight:281.82
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:281.1546421
Monoisotopic Mass:281.1546421
Topological Polar Surface Area:20.3
Heavy Atom Count:19
Complexity:262
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has the effects of vasodilation and central muscle relaxation. It can directly dilate vascular smooth muscle and inhibit multi-synaptic reflexes to reduce skeletal muscle tension. It can relieve muscle rigidity and clonus caused by brain and spinal cord damage, and increase peripheral blood flow.
Registered Holders
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SYN-TECH CHEM AND PHARM CO LTD
Active
United States
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Jinan JINDA Pharmaceutical Chemistry Co., Ltd.
Active
China
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Xi'an Li Bang Pharmaceutical Co., Ltd.
Active
China
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