Betamipron
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Betamipron
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CAS No:
3440-28-6
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Formula:
C10H11NO3
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Chemical Name:
Betamipron
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Synonyms:
β-Alanine,N-benzoyl-;N-Benzoyl-β-alanine;3-Benzamidopropionic acid;3-(Benzoylamino)propionic acid;Benzoyl-β-alanine;Betamipron;3-(Benzoylamino)propanoic acid;N-Benzoyl-β-aminopropionic acid;CS 443;NSC 192714;3-Benzamidopropanoicacid;3-Benzamidopropanoic acid
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CAS No:
Description
Betamipron is a chemical compound which is used together with Panipenem to inhibit Panipenem uptake into the renal tubule and prevent nephrotoxicity.
Solid
Betamipron is an organonitrogen compound and an organooxygen compound. It derives from a beta-amino acid.
Characteristics
66.4
0.5
Solid
1.227 g/cm3
120 °C
469.2°C at 760 mmHg
237.6ºC
1.557
>29 [ug/mL]
−20°C
LD50 in rats (mg/kg): >3000 i.v. (Hirouchi, 1994)
138.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Computed Properties
Molecular Weight:193.20
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:193.07389321
Monoisotopic Mass:193.07389321
Topological Polar Surface Area:66.4
Heavy Atom Count:14
Complexity:209
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Antibacterial effect: (1) Panipenem has a broad-spectrum antibacterial effect on gram-positive and gram-negative bacteria including anaerobic bacteria, and its antibacterial power is almost the same as that of imipenem. (2) Panipenem is stable to beta-lactamase produced by various bacteria. Efficacy of infection in experimental mice and rats: Panipenem has a good effect on intraperitoneal infection caused by various gram-positive and gram-negative bacteria including Staphylococcus aureus and Pseudomonas aeruginosa, and experimental infection in rats caused by Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and its efficacy is equal to or even better than that of imipenem. 3. Mechanism of action: Panipenem has a high affinity for penicillin-binding protein, which can hinder the synthesis of bacterial cell walls and thus play a bactericidal role.
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