Veratridine

673.79

673.79

200-758-4

DTXSID2058467

YELLOWISH-WHITE, AMORPHOUS POWDER

2929101000

178.61000

1.29390

white to off-white powder

1.45 g/cm3

180 °C

814.5ºC at 760 mmHg

446.4ºC

1.663

ethanol: 50 mg/mL

−20°C

Abdominal cavity-rat LD50: 3.5 mg/kg; abdominal cavity-mouse LD50: 1.35 mg/kg

Combustible, the fire emits spicy nitrogen oxides and stimulates smoke

D20 +8.0° (ethanol)

RETAINS WATER TENACIOUSLY

II

6.1(a)

UN 1544 6.1/PG 1

2

26/27/28-36/37/38-62-52/53-48/20

26-36/37/39-45-61-36/37-28

YX5600000

T+

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

P260-P262-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233

H300 + H310 + H330-H315-H319-H335-H361-H373-H412

A REVIEW, WITH 37 REFERENCES, OF RELEASE OF CATECHOLAMINE BY VERATRIDINE & SCORPION VENOM & ALTERATIONS IN EXTRACELLULAR K & NA.[PATON DM; RELEASE INDUCED BY ALTERATIONS IN EXTRACELLULAR POTASSIUM AND SODIUM AND BY VERATRIDINE AND SCORPION VENOM; RELEASE CATECHOLAMINES ADRENERGIC NEURONS 323 (1979)]|REVIEW OF NEURONAL SODIUM CHANNEL REGULATION BY NEUROTOXINS, INCLUDING VERATRIDINE.[KRUEGER BK, BLAUSTEIN MP; REGULATION OF NEURONAL SODIUM CHANNELS BY NEURO TOXINS; SHAMOO, AD (ED) ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, VOL 358 2ND INTERNATIONAL CONFERENCE ON CARRIERS AND CHANNELS IN BIOLOGICAL SYSTEMS: TRANSPORT PROTEINS; NEW YORK, NY, USA FEB 4-6, 348 (1980)]|REVIEW OF NEUROTOXINS, INCLUDING VERATRIDINE, THAT ACT ON VOLTAGE SENSITIVE SODIUM CHANNELS IN EXCITABLE MEMBRANES.[CATTERALL NA; NEURO TOXINS THAT ACT ON VOLTAGE SENSITIVE SODIUM CHANNELS IN EXCITABLE MEMBRANES; GEROGE R, OKUN R (ED). ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 20, 15 (1980)]

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P262, P264, P270, P271, P280, P281, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 129 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SLIGHT.

most toxic

THE ACTION OF VERATRIDINE ON THE RESTING MEMBRANE POTENTIAL OF INTACT CRAYFISH (PROCAMBARUS CLARKI) AXONS IN THE PRESENCE OF DIFFERENT EXTRACELLULAR ALKALINE-EARTH CATIONS WERE STUDIED USING INTRACELLULAR MICROELECTRODES. AT EXTRACELLULAR PH VALUES OF 7, 6, & 5, THE APPARENT BINDING SEQUENCE WAS CA2+ GREATER THAN OR EQUAL TO SR2+ MORE THAN MG2+ APPROX BA2+.

HAS BEEN TESTED IN MYASTHENIA GRAVIS TO INCREASE MUSCLE RESPONSE TO GIVEN MOTOR NEURON STIMULATION.|USED EXPERIMENTALLY TO ALTER SODIUM CHANNEL KINETICS /PRC: IN EXCITABLE MEMBRANES/

DATA GIVEN FOR LIPID SOLUBILITY, BINDING TO HUMAN ALBUMIN, & URINARY EXCRETION AFTER ORAL ADMIN TO HUMANS. STRUCTURE-ACTIVITY CORRELATIONS ARE DISCUSSED WITH RESPECT TO LIPID SOLUBILITY & PHARMACOLOGICAL PROPERTIES.

THE EFFECTS OF VERATRIDINE ON EXCITABLE TISSUES ARE PREDICTABLE, BASED ON ITS ABILITY TO ENHANCE SODIUM PERMEABILITY. EFFECTS INCLUDE, AMONG OTHERS, RELEASE OF NEUROTRANSMITTERS, HORMONES, DRUGS TAKEN UP BY NERVE ENDINGS, ETC.

Veratridine

COMPONENT OF SABADILLA (USED AS AN INSECTICIDE)