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N4-Acetylcytidine

N4-Acetylcytidine structure

CAS No:
3768-18-1
Formula:
C11H15N3O6
Chemical Name:
N4-Acetylcytidine
Synonyms:
Cytidine,N-acetyl-;Acetamide,N-(1,2-dihydro-2-oxo-1-β-D-ribofuranosyl-4-pyrimidinyl)-;N-Acetylcytidine;N4-Acetylcytidine;4-Acetylcytidine;N4-Acetylcytidine
Categories:
Biochemical Engineering > Saccharides

Description

N4-Acetylcytidine is an endogenous metabolite.

Solid

N(4)-acetylcytidine is cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group. It has a role as a metabolite. It is a member of cytidines, a member of acetamides and a secondary carboxamide.

N4-Acetylcytidine Basic Attributes

Molecular Weight：

285.25

Exact Mass：

285.25

EC Number：

223-195-6

HScode：

2934999090

Characteristics

PSA：

132

XLogP3：

-1.4

Appearance：

Solid

Density：

1.7±0.1 g/cm3

Melting Point：

208-209 °C

Refractive Index：

1.699

Storage Conditions：

−20°C

Collision Cross Section：

162.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|161.4 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

Safety Information

wgk germany：

hazard class code：

20/21/22-36/37/38

safety instructions：

36-36/37/39-26

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

4-acetylcytidine

N4-Acetylcytidine Use and Manufacturing

In a 500 mL three-necked flask was added 50.0 g of Compound 3 powder and 250 mL of acetonitrile and 25 mL of acetic anhydride, stirred and refluxed for 3 h, cooled to room temperature and filtered with suction. The solid was washed with acetonitrile twice and the filter cake was dried to give 56.3 g of compound 4 with a yield of 96.0 percent.To a solution of cytidine (1.22 g, 5.00 mmol) in DMF(40 mL) is added acetic anhydride (0.94 mL, 10.00 mmol). The solution is treated with microwave radiation (Panasonic, 1000 Watts) at full power for 40 seconds. The solution is concentrated in vacuo and the residue is co-evaporated with methanol (2.x.20 mL) to give 4-N-acetyl-cytidine (1.43 g, 95.0percent) as a white powder. MS (FAB):m/z 286 (MHCytidine (100.Og, 0.41 mol) was dissolved in DMF (500 ml), acetic anhydride (42.5 ml, 45.9 g, 0.45 mol) was added and the whole was left for 24 h. Solvent was evaporated, the residue boiled with methanol (40 ml) and cooled. Crystals were filtered and dried to furnish Λ^-acetylcytidine (102 g, 87.0percent).claim 1wherein the compound is...5-Fluorocytidine, 1-(beta-D -arabinofuranosyl)-5-fluorocytosine, 5-Methylcytidine, 2', 3'-Dideoxycytidine, N4-Acetylcytidine, 3'-Deoxycytidine, 4-Methoxy-1-(beta-D-ribofuranosyl)pyrimidin-2(1H)-one, 4-Methylthio-1-(beta-D-ribofuranosyl)pyrimidin-2(1H)-one, ...

Computed Properties

Molecular Weight:285.25
XLogP3:-1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:285.09608521
Monoisotopic Mass:285.09608521
Topological Polar Surface Area:132
Heavy Atom Count:20
Complexity:477
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of N4-Acetylcytidine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

N4-Acetylcytidine

CAS No.: 3768-18-1

Content: 99.00%

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

N4-Ac-Cr

CAS No.: 3768-18-1

Grade: Analytical Reagent

Content: 99%

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Guide of N4-Acetylcytidine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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N4-Acetylcytidine

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