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Fluorometholone acetate

Fluorometholone acetate structure

CAS No:
3801-06-7
Formula:
C24H31FO5
Chemical Name:
Fluorometholone acetate
Synonyms:
Pregna-1,4-diene-3,20-dione,17-(acetyloxy)-9-fluoro-11-hydroxy-6-methyl-,(6α,11β)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,17-dihydroxy-6α-methyl-,17-acetate;(6α,11β)-17-(Acetyloxy)-9-fluoro-11-hydroxy-6-methylpregna-1,4-diene-3,20-dione;U 17323;6α-Methyl-9α-fluoro-17-acetoxy-21-deoxyprednisolone;Oxylone acetate;6α-Methyl-9α-fluoro-21-desoxyprednisolone-17-acetate;Fluorometholone acetate;Flarex;NSC 47438;Eflone;80571-63-7
Categories:
Biochemical Engineering > Inhibitors

Description

Off-White to Pale Yellow Solid

Fluorometholone acetate is a steroid ester resulting from the formal condensation of the 17-hydroxy function of fluorometholone with acetic acid. Used in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye. It has a role as an anti-inflammatory drug. It is a steroid ester, a glucocorticoid, a 3-oxo-Delta(1),Delta(4)-steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, an acetate ester and a fluorinated steroid. It derives from a Delta(1)-progesterone and a fluorometholone.|Fluorometholone Acetate is the acetate salt form of fluorometholone, a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Fluorometholone acetate exerts its effect by interacting with cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.

Fluorometholone acetate Basic Attributes

Molecular Weight：

418.4983432

Exact Mass：

418.50

EC Number：

223-270-3

UNII：

9I50C3I3OK

NSC Number：

47438

DSSTox ID：

DTXSID20191424

NCI Thesaurus Code：

C47535

HScode：

2942000000

Characteristics

PSA：

80.7

XLogP3：

2.57

Density：

1.2±0.1 g/cm3

Melting Point：

292-303 °C

Boiling Point：

532.1±50.0 °C at 760 mmHg

Flash Point：

275.6±30.1 °C

Refractive Index：

1.556

Specific rotation：

D +28° (chloroform)

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P201, P202, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Danger|H315 (66.67%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P260, P261, P264, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P314, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fluorometholone acetate Use and Manufacturing

Uses

Fluorometholone Acetate is a glucocorticoid; anti-inflammatory.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:418.5
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:418.21555225
Monoisotopic Mass:418.21555225
Topological Polar Surface Area:80.7
Heavy Atom Count:30
Complexity:892
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Fluorometholone acetate CAS 3801-06-7

CAS No.: 3801-06-7

Grade: Pharmaceutical Grade

Content: 99%

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