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Dapsone

Dapsone structure

CAS No:
80-08-0
Formula:
C12H12N2O2S
Chemical Name:
Dapsone
Synonyms:
Benzenamine,4,4′-sulfonylbis-;Aniline,4,4′-sulfonyldi-;4,4′-Sulfonylbis[benzenamine];1358F;F 1358;Avlosulfon;Avlosulfone;Bis(4-aminophenyl) sulfone;Croysulfone;DADPS;Dapsone;DDS;p,p′-Diaminodiphenyl sulfone;4,4′-Diaminodiphenyl sulfone;Di(p-aminophenyl) sulfone;Diaphenylsulfone;Di(4-aminophenyl)sulfone;Diphenasone;Diphone;Disulone;DSS;Dumitone;Eporal;Metabolite C;Novophone;Sulfona-Mae;p,p′-Sulfonyldianiline;4,4′-Sulfonyldianiline;Sulphadione;4,4′-Sulphonyldianiline;Udolac;DDS (pharmaceutical);Bis(p-aminophenyl) sulfone;4-Aminophenyl sulfone;4,4′-Sulfonylbisbenzamine;1,1′-Sulfonylbis[4-aminobenzene];Sulfona;p-Aminophenyl sulfone;Diaphenylsulfon;Dapson;4,4′-Sulfonylbisaniline;HT 976;Araldite HT 976;Sumicure S;Hardener HT 976;4,4′-Dapsone;HT 9664;Seikacure S;NSC 6091;HY 976;Aradur 976-1;HT 976-1;Servidapson;4,4′-DDS;4,4′-Sulfonyldiphenylamine;DADFS;HB-MC-GE 40;HB-MC-GE 45;Lapox K 10;Aczone;Atrisone;Aradur 9664-1;4-(4-Aminophenylsulfonyl)benzenamine;4-(4-Aminophenyl)sulfonylaniline;Aradur 9761-1;4,4′-Diaminobiphenyl sulfone;HEW 62;Aradur 976;D 0089;Aradur 9664-1NL;K 10;44DDS;1246638-15-2
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and an

Dapsone Basic Attributes

Molecular Weight：

248.3

Exact Mass：

248.30

BRN：

788055

EC Number：

201-248-4

HScode：

2921590090

Characteristics

PSA：

94.6

XLogP3：

Appearance：

White to beige Crystalline Powder

Density：

1.392 g/cm³

Melting Point：

175-176 °C

Boiling Point：

511.7°C at 760 mmHg

Flash Point：

greater than 320° F (NTP, 1992)

Refractive Index：

1.662

Water Solubility：

H2O: <0.1 g/100 mL at 20 ºC

Storage Conditions：

-20°C Freezer

Vapor Pressure：

2.68X10-8 mm Hg at 25 deg C (est)

Vapor Density：

8.3 (Air = 1)

Toxicity：

Oral-rat LD50: 1000 mg/kg; Oral-Mouse LD50: 250 mg/kg

Odor：

Odorless

Taste：

Slightly bitter taste

PKA：

2.41None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

BY8925000

Marks：

Storage features：

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stability/Shelf Life：

Stable. Combustible. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Toxicity

Toxicity class：

highly toxic

Dapsone Use and Manufacturing

Hardening agent in the curing of epoxy resins.

Computed Properties

Molecular Weight:248.30
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:248.06194880
Monoisotopic Mass:248.06194880
Topological Polar Surface Area:94.6
Heavy Atom Count:17
Complexity:306
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dapsone Tablets
Ingredients	Dapsone. Chemical name: 4,4-sulfonyl dianiline Molecular weight: C12H12N2O2S
Indication	1. When used in combination with probenecid, it can reduce the secretion of sulfones by the renal tubules, resulting in high and prolonged blood concentrations of sulfone drugs, which are prone to toxic reactions. Therefore, the dose of sulfones needs to be adjusted while or after the use of probenecid. 2. Rifampicin can stimulate the activity of liver microsomal enzymes, reducing the blood concentration of this product by 1/7 to 1/10. Therefore, when dapsone is used while or after taking rifampicin, the dose of the latter needs to be adjusted. 3. This product should not be used in combination with bone marrow suppressive drugs, as it can aggravate the degree of leukopenia and thrombocytopenia. If it must be used in combination, the toxicity to the bone marrow should be closely observed. 4. When this product is used in combination with other hemolytic drugs, it can aggravate the hemolytic reaction. 5. When used in combination with trimethoprim, the blood concentrations of both drugs can be increased. The possible mechanisms are: (1) Inhibition of dapsone metabolism in the liver. (2) Competition between the two for excretion in the kidneys.
Specifications	50mg*24s
Manufacturer	Shanghai Sine Tianping Pharmaceutical Co., Ltd.

Dapsone Tablets
Ingredients	The main component of this product is 4,4'-sulfonyl dianiline
Indication	1. When used in combination with probenecid, it can reduce the secretion of sulfones by the renal tubules, resulting in high and persistent blood concentrations of sulfone drugs, which are prone to toxic reactions. Therefore, the dose of sulfones needs to be adjusted at the same time or after the use of probenecid. 2. Rifampicin can stimulate the activity of liver microsomal enzymes, reducing the blood concentration of this product by 1/7-1/10. Therefore, when taking rifampicin at the same time or after the use of dapsone, the dose of the latter needs to be adjusted. 3. This product should not be used in combination with bone marrow suppressive drugs, because it can aggravate the degree of leukopenia and thrombocytopenia. If it must be used in combination, the toxicity to the bone marrow should be closely observed. 4. When this product is used in combination with other hemolytic drugs, the hemolytic reaction can be aggravated. 5. When used in combination with trimethoprim, the blood concentrations of both drugs can be increased. The mechanism may be: (1) Inhibition of the metabolism of dapsone in the liver. (2) The two compete for excretion in the kidneys. The increase in the blood concentration of this product can aggravate its adverse reactions. 6. The absorption of this product can be reduced when used in combination with didanosine, because oral didanosine requires the simultaneous administration of buffer to neutralize gastric acid, and this product requires an acidic environment to increase absorption. Therefore, if the two must be used together, there should be at least 2 hours between them.
Specifications	50mg
Manufacturer	Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.

Dapsone Tablets
Ingredients	The main component of this product is 4,4'-sulfonyl dianiline
Indication	1. When used in combination with probenecid, it can reduce the secretion of sulfones by the renal tubules, resulting in high and persistent blood concentrations of sulfone drugs, which are prone to toxic reactions. Therefore, the dose of sulfones needs to be adjusted at the same time or after the use of probenecid. 2. Rifampicin can stimulate the activity of liver microsomal enzymes, reducing the blood concentration of this product by 1/7-1/10. Therefore, when taking rifampicin at the same time or after the use of dapsone, the dose of the latter needs to be adjusted. 3. This product should not be used in combination with bone marrow suppressive drugs, because it can aggravate the degree of leukopenia and thrombocytopenia. If it must be used in combination, the toxicity to the bone marrow should be closely observed. 4. When this product is used in combination with other hemolytic drugs, the hemolytic reaction can be aggravated. 5. When used in combination with trimethoprim, the blood concentrations of both drugs can be increased. The mechanism may be: (1) Inhibition of the metabolism of dapsone in the liver. (2) The two compete for excretion in the kidneys. The increase in the blood concentration of this product can aggravate its adverse reactions. 6. The absorption of this product can be reduced when used in combination with didanosine, because oral didanosine requires the simultaneous administration of buffer to neutralize gastric acid, and this product requires an acidic environment to increase absorption. Therefore, if the two must be used together, there should be at least 2 hours between them.
Specifications	50mg
Manufacturer	KPC Pharmaceuticals, Inc.

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Registered Holders

NOVITIUM PHARMA LLC

United States
Active
SAI LIFE SCIENCES LTD

United States
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Extrovis AG

Switzerland
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