8-Hydroxyguanosine
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8-Hydroxyguanosine
structure -
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CAS No:
3868-31-3
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Formula:
C10H13N5O6
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Chemical Name:
8-Hydroxyguanosine
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Synonyms:
Guanosine,7,8-dihydro-8-oxo-;Purine-6,8(1H,9H)-dione,2-amino-9-β-D-ribofuranosyl-;7,8-Dihydro-8-oxoguanosine;8-Hydroxyguanosine;8-Oxoguanosine;8-Oxo-7,8-dihydroguanosine;NSC 90393;Chembridge 5144558;NQZ-013;29851-58-9;448192-32-3
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CAS No:
Description
8-Hydroxyguanosine is a systematic marker of oxidative stress and a marker of hydroxyl radical damage to RNA.
Characteristics
170
-0.97
2.4±0.1 g/cm3
232-235°C
2.007
-20°C Freezer
sce-hmn-lym 100 nmol/L MUREAV 403,223,1998
Safety Information
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)
7,8-dihydro-8-oxoguanosine
8-Hydroxyguanosine Use and Manufacturing
It is a representative metabolite derived by the oxidation of Guanosine (G) and is regarded as a marker of oxidative stress in the cells.
Computed Properties
Molecular Weight:299.24
XLogP3:-3.6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:299.08658315
Monoisotopic Mass:299.08658315
Topological Polar Surface Area:170
Heavy Atom Count:21
Complexity:574
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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