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Cucurbitacin D

Cucurbitacin D structure

CAS No:
3877-86-9
Formula:
C30H44O7
Chemical Name:
Cucurbitacin D
Synonyms:
19-Norlanosta-5,23-diene-3,11,22-trione,2,16,20,25-tetrahydroxy-9-methyl-,(2β,9β,10α,16α,23E)-;19-Nor-9β,10α-lanosta-5,23-diene-3,11,22-trione,2β,16α,20,25-tetrahydroxy-9-methyl-;(2β,9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione;Elatericin A;Cucurbitacin D;NSC 521776;Cucurbitacine D;Elatericine A;NSC 308606;(+)-Cucurbitacin D;28973-72-0;204376-96-5
Categories:
Biochemical Engineering > Plant Extracts

Description

Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1].

Cucurbitacin D Basic Attributes

Molecular Weight：

516.67

Exact Mass：

516.67

HScode：

29144000

Characteristics

PSA：

132.13000

XLogP3：

1.48

Density：

1.2±0.1 g/cm3

Melting Point：

149-150 °C (decomp)

Boiling Point：

684.0±55.0 °C at 760 mmHg

Flash Point：

381.4±28.0 °C

Refractive Index：

1.582

Toxicity：

Oral-Rat LD50: 8.2 mg/kg; Oral-Mouse LD50: 5 mg/kg

Flammability characteristics：

Flammable, spicy and irritating smoke emitted from the fire

Safety Information

Marks：

Storage features：

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

Toxicity

Toxicity class：

most toxic

Computed Properties

Molecular Weight:516.7
XLogP3:2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:516.30870374
Monoisotopic Mass:516.30870374
Topological Polar Surface Area:132
Heavy Atom Count:37
Complexity:1100
Undefined Atom Stereocenter Count:9
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Cucurbitacin D

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Computed Properties
Learn More Other Chemicals

Cucurbitacin D

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