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Bufotalin

Bufotalin structure

CAS No:
471-95-4
Formula:
C26H36O6
Chemical Name:
Bufotalin
Synonyms:
Bufa-20,22-dienolide,16-(acetyloxy)-3,14-dihydroxy-,(3β,5β,16β)-;5β-Bufa-20,22-dienolide,3β,14,16β-trihydroxy-,16-acetate;(3β,5β,16β)-16-(Acetyloxy)-3,14-dihydroxybufa-20,22-dienolide;Bufotalin;3β,14,16β-Trihydroxy-5β-bufa-20,22-dienolide 16-acetate;NSC 89596;107176-12-5
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Bufotalin is a cardiotoxic bufanolide steroid, cardiac glycoside analogue, secreted by a number of toad species; a novel anti-osteoblastoma agent.IC50 value:Target:in vitro: bufotalin induced osteoblastoma cell death and apoptosis in dose- and time-dependent manners. Further, bufotalin induced endoplasmic reticulum (ER) stress activation in osteoblastoma cells, the latter was detected by the induction of C/EBP homologous protein (CHOP), phosphorylation of inositol-requiring enzyme 1 (IRE

Bufotalin Basic Attributes

Molecular Weight：

444.560

Exact Mass：

444.56

HScode：

29329990

Characteristics

PSA：

96.97000

XLogP3：

2.54

Appearance：

White to off-white solid.

Density：

1.3±0.1 g/cm3

Melting Point：

223 °C (decomp)

Boiling Point：

591.7±50.0 °C at 760 mmHg

Flash Point：

195.8±23.6 °C

Refractive Index：

1.587

Vapor Pressure：

1.82E-16mmHg at 25°C

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3172

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Bufotaline

CAS No.: 471-95-4

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