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Trifluoperazine hydrochloride

Trifluoperazine hydrochloride structure

CAS No:
440-17-5
Formula:
C21H24F3N3S.2ClH
Chemical Name:
Trifluoperazine hydrochloride
Synonyms:
10H-Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-,hydrochloride (1:2);Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-,dihydrochloride;10H-Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-,dihydrochloride;Trifluoperazine dihydrochloride;2-Trifluoromethyl-10-[3′-(1-methyl-4-piperazinyl)propyl]phenothiazine dihydrochloride;Fluoperazine;Trifluoperazine hydrochloride;Trifluoroperazine hydrochloride;Stelazine;Jatroneural;2-Trifluoromethyl-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine dihydrochloride;Triphthazine dihydrochloride;Tryptazine dihydrochloride;Eskazine;Trifluoroperazine dihydrochloride;SKF 5019;Terfluzine;Triftazin;Tryptazine;Triphthazine;Eskazinyl;Trazine;Modalina;Triphthasine;TFP;Stellasil;10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Trifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Target: Dopamine D2 ReceptorTrifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. Trifluoperazine inhibited in a dose-dependent manner the stimulation of glycogenolysis, gluconeogenesis, and ureogenesis due to alpha 1-adrenergic stimulation in rat hepatocytes. Trifluoperazine is much more potent at alpha 1-

Trifluoperazine Hydrochloride is the hydrochloride salt of trifluoperazine, a phenothiazine derivative and a dopamine, alpha-adrenergic, and anticholinergic antagonist with antipsychotic, anxiolytic, and antiemetic activities. Trifluoperazine blocks central dopamine receptors, which may prevent or mitigate delusions and hallucinations caused by an excess of dopamine; dopamine blockade in the chemoreceptor trigger zone (CTZ) may result in an antiemetic effect. This agent binds to central adrenergic receptors, which may result in anxiolytic effects. Trifluoperazine also functions as a calmodulin inhibitor, elevating cytosolic calcium.|A phenothiazine with actions similar to CHLORPROMAZINE. It is used as an antipsychotic and an antiemetic.

Trifluoperazine hydrochloride Basic Attributes

Molecular Weight：

480.42

Exact Mass：

479.117645

EC Number：

207-123-0

UNII：

6P1Y2SNF5V

DSSTox ID：

DTXSID1045085

NCI Thesaurus Code：

C904

HScode：

29343000

Characteristics

PSA：

XLogP3：

5.03 @ 25 deg C

Appearance：

white to off-white

Melting Point：

242-243 °C

Boiling Point：

202-210 deg C @ 0.6 mm Hg

Flash Point：

9℃

Water Solubility：

ethanol: soluble 5mg/mL

Storage Conditions：

2-8°C

Vapor Pressure：

2.32E-10mmHg at 25°C

Collision Cross Section：

188.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

SP1750000

Marks：

Stability/Shelf Life：

Hygroscopic

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

Apo Trifluoperazine

Trifluoperazine hydrochloride Use and Manufacturing

Uses

Antipsychotic

Manufacturing Info：

10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:480.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:479.1176589
Monoisotopic Mass:479.1176589
Topological Polar Surface Area:35
Heavy Atom Count:30
Complexity:510
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a phenothiazine antipsychotic. Its antipsychotic effect is related to its blocking of dopamine receptors in the brain, inhibiting dopamine receptors in the emetic chemoreceptor area of the medulla oblongata and directly inhibiting the vomiting center, producing a strong antiemetic effect, but weak sedative and anticholinergic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Trifluoperazine Hydrochloride Tablets
Ingredients	The main ingredient of this product is trifluoperazine hydrochloride, and its chemical name is: 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-phenothiazine dihydrochloride.
Indication	1. When used in combination with ethanol or other central nervous system depressants, it can enhance the central inhibitory effect. 2. When used in combination with antihypertensive drugs, it can easily cause postural hypotension. 3. When used in combination with sultopride, this product increases the risk of ventricular arrhythmia, and in severe cases, it can cause torsades de pointes arrhythmia. 4. When used in combination with other atropine drugs, adverse reactions are additive.
Specifications	5mg
Manufacturer	Shanghai Sine Pharmaceutical Laboratories Co., Ltd.

Trifluoperazine Hydrochloride Tablets
Ingredients	The main ingredient of this product is trifluoperazine hydrochloride, and its chemical name is: 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-phenothiazine dihydrochloride.
Indication	1. When used in combination with ethanol or other central nervous system depressants, it can enhance the central inhibitory effect. 2. When used in combination with antihypertensive drugs, it can easily cause postural hypotension. 3. When used in combination with sultopride, this product increases the risk of ventricular arrhythmia, and in severe cases, it can cause torsades de pointes arrhythmia. 4. When used in combination with other atropine drugs, adverse reactions are additive.
Specifications	5mg
Manufacturer	Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.

Registered Holders

TRIFARMA SPA

Brazil
Active
Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.

China
Active
FINE CHEMICALS CORP

United States
Inactive

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CAS No.: 440-17-5

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Trifluoperazine dihydrochloride

CAS No.: 440-17-5

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Guide of Trifluoperazine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

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