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(-)-Nuciferine

(-)-Nuciferine structure

CAS No:
475-83-2
Formula:
C19H21NO2
Chemical Name:
(-)-Nuciferine
Synonyms:
4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-,(6aR)-;6aβ-Aporphine,1,2-dimethoxy-;Nuciferine;4H-Dibenzo[de,g]quinoline,5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-,(R)-;(6aR)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline;l-Nuciferine;(-)-Nuciferine;(R)-1,2-Dimethoxyaporphine;Nuciferin;D-(-)-Nuciferine;1,2-Dimethoxy-6aβ-aporphine;Sanjoinine E;(R)-Nuciferine;VLT 049;(6AR)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Categories:
Biochemical Engineering > Chinese Herbs

Description

Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.

(-)-Nuciferine Basic Attributes

Molecular Weight：

295.37600

Exact Mass：

295.38

UNII：

W26UEB90B7

HScode：

29389090

Characteristics

PSA：

21.70000

XLogP3：

3.4

Density：

1.15g/cm3

Melting Point：

162.5-163.5 °C

Boiling Point：

430.7ºC at 760mmHg

Flash Point：

151.9ºC

Refractive Index：

1.596

Vapor Pressure：

1.27E-07mmHg at 25°C

Toxicity：

LD50 orl-rat: 280 mg/kg AIPTAK 197,261,72

Safety Information

safety instructions：

24/25

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

l-5,6-dimethoxyaporphine

Computed Properties

Molecular Weight:295.4
XLogP3:3.4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:295.157228913
Monoisotopic Mass:295.157228913
Topological Polar Surface Area:21.7
Heavy Atom Count:22
Complexity:401
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of (-)-Nuciferine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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(-)-Nuciferine

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