(-)-Dehydrocostus lactone
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(-)-Dehydrocostus lactone
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CAS No:
477-43-0
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Formula:
C15H18O2
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Chemical Name:
(-)-Dehydrocostus lactone
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Synonyms:
Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-tris(methylene)-,(3aS,6aR,9aR,9bS)-;Costus lactone,dehydro-;Guaia-4(15),10(14),11(13)-trien-12-oic acid,6α-hydroxy-,γ-lactone;Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-tris(methylene)-,[3aS-(3aα,6aα,9aα,9bβ)]-;(3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one;Dehydrocostus lactone;Epiligulyl oxide;(-)-Dehydrocostus lactone
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CAS No:
Description
Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa.IC50 value:Target:In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation b
Dehydrocostus lactone is an organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. It has a role as a metabolite, a trypanocidal drug, an antineoplastic agent, a cyclooxygenase 2 inhibitor, an antimycobacterial drug and an apoptosis inducer. It is a sesquiterpene lactone, a guaiane sesquiterpenoid, an organic heterotricyclic compound and a gamma-lactone.
Characteristics
26.3
2.6
1.1±0.1 g/cm3
61 °C
140-143 °C @ Press: 0.5 Torr
161.2±25.3 °C
1.536
room temp
4.31E-06mmHg at 25°C
Safety Information
III
6.1
2811
3
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
24/25
Xn
Computed Properties
Molecular Weight:230.30
XLogP3:2.6
Hydrogen Bond Acceptor Count:2
Exact Mass:230.130679813
Monoisotopic Mass:230.130679813
Topological Polar Surface Area:26.3
Heavy Atom Count:17
Complexity:432
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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