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3-Fluoro-2-methylaniline

3-Fluoro-2-methylaniline structure

CAS No:
443-86-7
Formula:
C7H8FN
Chemical Name:
3-Fluoro-2-methylaniline
Synonyms:
Benzenamine,3-fluoro-2-methyl-;o-Toluidine,3-fluoro-;3-Fluoro-2-methylbenzenamine;3-Fluoro-2-methylaniline;6-Amino-2-fluorotoluene;1-Amino-3-fluoro-2-methylbenzene;2-Methyl-3-fluoroaniline;(3-Fluoro-2-methylphenyl)amine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

clear yellowish liquid

3-Fluoro-2-methylaniline Basic Attributes

Molecular Weight：

125.146

Exact Mass：

125.14

EC Number：

207-142-4

UNII：

W95WMY5PM6

DSSTox ID：

DTXSID20196111

HScode：

2921430090

Characteristics

PSA：

XLogP3：

1.7

Appearance：

yellow clear liquid

Density：

1.1±0.1 g/cm3

Melting Point：

7 °C

Boiling Point：

89.5-90.5 °C @ Press: 15 Torr

Flash Point：

86.1±0.0 °C

Refractive Index：

1.542

Storage Conditions：

Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure：

0.447mmHg at 25°C

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

2810

wgk germany：

hazard class code：

R23/24/25;R36/37/38

safety instructions：

S45-S36/37/39-S26-S36/37

Marks：

T:Toxic;

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302 + H312 + H332-H315-H319-H335

3-Fluoro-2-methylaniline Use and Manufacturing

To a solution of General procedure: The solution of 4-methoxybenzene-1, 3-disulfonyldichloride(8) (0.87 g, 2.9 mmol) in anhydrous THF (15 mL) wasadded to pyridine (1 mL) and 3-bromine-4-methylanilin(1.07 g, 5.8 mmol). This solution was stirred rapidly at roomtemperature for about 2 h and then was refluxed for 10 h.The resulting solution was concentrated in vacuo and thesolvent was removed. The residue was recrystallized frommethanol-water to terminal compound 2a (1.20 g, yield68.5%).The other compounds (2b-2i) were prepared with thesimilar method of preparing compound 2a.General procedure: The solution of 4-methoxy-1, 3-benzenedichloride (6)(0.93 g, 4.0 mmol) in anhydrous THF (15 mL) was added to3-bromine-4-methylaniline (1.48 g, 8.0 mmol). This solutionwas stirred rapidly at room temperature for about 1 hand then pyridine (1 mL) was added. The solution wasrefluxed for 4-8 h. The residue was recrystallized frommethanol-water to terminal compound 1a (1.81 g, yield85.2%). The other compounds (1b-1i) were prepared with thesimilar method of preparing compound 1a.

Computed Properties

Molecular Weight:125.14
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:125.064077422
Monoisotopic Mass:125.064077422
Topological Polar Surface Area:26
Heavy Atom Count:9
Complexity:94.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Fluoro-2-methylaniline

Qingdao Orient Chemical Co.,LTD Contact Supplier

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3-Fluoro-2-methylaniline 443-86-7

CAS No.: 443-86-7

Grade: Industrail Grade

Content: 99%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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3-Fluoro-2-methylaniline

CAS No.: 443-86-7

Content: 99.00%

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