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Ginkgetin

Ginkgetin structure

CAS No:
481-46-9
Formula:
C32H22O10
Chemical Name:
Ginkgetin
Synonyms:
4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-;3′′′,8-Biflavone,4′,5,5′′,7-tetrahydroxy-4′′′,7′′-dimethoxy-;5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Ginkgetin;Amentoflavone 7′′,4′′′-dimethyl ether;7,4′-Dimethylamentoflavone;Ginkgotin
Categories:
Biochemical Engineering > Chinese Herbs

Description

Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L; effects of anti-inflammation and anticancer have been reported.IC50 value:Target:in vitro: Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. Ginkgetin consistently inhibited the production of leukotriene C(4) (LTC(4)) in a dose dependent manner, with an IC(50) value of

Solid

Ginkgetin is a biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. It has a role as an anti-HSV-1 agent, a cyclooxygenase 2 inhibitor, an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, an antineoplastic agent and a metabolite. It is a biflavonoid, a hydroxyflavone, a methoxyflavone and a ring assembly. It derives from an amentoflavone.

Ginkgetin Basic Attributes

Molecular Weight：

566.51

Exact Mass：

566.51

UNII：

HY5EZW8269

DSSTox ID：

DTXSID70197416

Characteristics

PSA：

152

XLogP3：

4.45

Appearance：

Solid

Density：

1.5±0.1 g/cm3

Melting Point：

297 °C @ Solvent: Acetone

Boiling Point：

863.7±65.0 °C at 760 mmHg

Flash Point：

287.2±27.8 °C

Refractive Index：

1.714

Water Solubility：

0.002419 mg/L @ 25 °C (est)

Vapor Pressure：

2.28E-31mmHg at 25°C

Drug Information

MeSH Entry Terms：

ginkgetin

Ginkgetin Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Biflavonoids and polyflavonoids [PK1204]

Computed Properties

Molecular Weight:566.5
XLogP3:5.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:566.12129689
Monoisotopic Mass:566.12129689
Topological Polar Surface Area:152
Heavy Atom Count:42
Complexity:1080
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Regulation of the circulatory system: It produces arterial relaxation by stimulating the release of catecholamines and inhibiting their degradation, as well as stimulating the production of prostacyclin and endothelial relaxing factor, thereby maintaining the tension of arteries and veins.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ginkgo biloba extract drops
Ingredients	The main ingredients are 40 mg of ginkgo leaf extract per milliliter, including 9.6 mg of ginkgo flavonoids and 2.4 mg of terpenes (ginkgolides, bilobalide).
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	30ml:1.2g

Ginkgo Leaf Drops
Ingredients	Each milliliter is labeled to contain 9.6 mg of ginkgo flavonoids, 2.4 mg of terpenes, ginkgo lactones, and ginkgo biloba.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	36ml (drops)
Manufacturer	Shandong Xianhe Pharmaceutical Co., Ltd.

Ginkgo biloba extract tablets
Ingredients	Each tablet contains 4 mg of ginkgo leaf extract, including 9.6 mg of ginkgo flavonoids and 2.4 mg of terpene lactones (ginkgolides and bilobalide).
Indication	Each tablet contains 4 mg of ginkgo leaf extract, including 9.6 mg of ginkgo flavonoids and 2.4 mg of terpene lactones (ginkgolides and bilobalide).
Specifications	40mg x 10 tablets x 2 plates film coated

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Ginkgetin 98% Purity Biflavonoid Standard CAS 481-46-9 Research Grade Reference Standard

Unit Price: $43-51 /G FOB

CAS No.: 481-46-9

Grade: Analytical Reagent

Content: 98%

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Ginkgetin

Unit Price: nullnull /null null

CAS No.: 481-46-9

Grade: Pharmaceutical grad

Content: 99%

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Guide of Ginkgetin

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Recommended Suppliers
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