1,3-Dibromopropane

201.89

201.89

203-690-3

YQR3048IX9

62663

DTXSID1021902

Colorless liquid

29033036

0

2.4

Clear colorless to yellow Liquid

1.98927 g/cm³ @ Temp: 15 °C

-34.2 °C

167.3 °C

54 °C

n 20/D 1.524(lit.)

H2O: 1.7 g/L (30 ºC)

2-8°C

2.6 hPa (20 °C)

7 (vs air)

Abdominal cavity-mouse LD50: 473 mg/kg

Combustible, the fire emits bromine spicy irritating smoke

Sweet odor

8.88e-04 atm-m3/mole|Henry's Law constant = 8.88X10-4 atm-cu m/mol at 25 °C

Hydroxyl radical reaction rate constant = 8.4X10-13 cu cm/molec-sec at 25 °C (est)

III

3

UN 1993 3/PG 3

2

10-22-38-51/53-36/37/38

16-26-36-61-24/25

TX8575000

Xn,N,Xi

The warehouse is ventilated, low temperature and dry; stored and transported separately from food, oxidants and acids

Stable. Incompatible with strong oxidizing agents, strong bases. Flammable.

P273, P391, P501

H401

|Warning|H226 (96.55%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P270, P273, P280, P301+P312, P302+P352, P303+P361+P353, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P370+P378, P391, P403+P235, and P501|Aggregated GHS information provided by 110 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Danger|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P303+P361+P353, P307+P311, P314, P321, P370+P378, P403+P235, P405, and P501

Personnel Protection: ... Wear appropriate chemical protective gloves, boots and goggles. /Bromopropanes/

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources. /Bromopropanes/

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Use alcohol foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources. /Bromopropanes/|Personnel protection: Avoid breathing vapors. Keep upwind. Do not handle broken packages unless wearing appropriate personal protective equipment. If contact with the material anticipated, wear appropriate chemical protective clothing. /Bromopropanes/

highly toxic

LD50 Mouse ip 473 mg/kg

1,3-Dibromopropane's production and use as an intermediate for dyestuff and pharmaceutical industries, and in the manufacture of cyclopropane(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 460(SRC), determined from a measured log Kow of 2.37(2) and a regression derived equation(3), indicates that 1,3-dibromopropane is expected to have moderate mobility in soil(SRC). Volatilization of 1,3-dibromopropane from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 8.88X10-4 atm-cu m/mole(4). The potential for volatilization of 1,3-dibromopropane from dry soil surfaces exists(SRC) based upon its vapor pressure of 1.36 mm Hg(4). Biodegradation data were not available(SRC, 2005).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 460(SRC), determined from a measured log Kow of 2.37(2) and a regression derived equation(3), indicates that 1,3-dibromopropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 8.88X10-4 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hours and 6 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 13(SRC), from log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-life of 1,3-dibromopropane is about 48 days at pH 7 and 25 °C(7). Biodegradation data were not available(SRC, 2005).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-dibromopropane, which has a vapor pressure of 1.36 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,3-dibromopropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 days(SRC), calculated from its rate constant of 8.4X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

The rate constant for the vapor-phase reaction of 1,3-dibromopropane with photochemically-produced hydroxyl radicals has been estimated as 8.4X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 19 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,3-Dibromopropane is not expected to undergo direct photolysis in the environment since it does not contain functional groups that absorb light in the environmental UV spectrum(2). The hydrolysis half-life of 1,3-dibromopropane is about 48 days at pH 7 and 25 °C(3).

An estimated BCF of 13 was calculated for 1,3-dibromopropane (SRC), using a measured log Kow of 2.37(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 1,3-dibromopropane is estimated as 460(SRC), using a measured log Kow of 2.37(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,3-dibromopropane is expected to have moderate mobility in soil(SRC). Adsorption isotherms for 1,3-dibromopropane were calculated using a highly organic Florida Pahokee soil(4). The adsorption isotherms were non linear with an average soil adsorption coefficient (Kd) of 22.5 L/kg(4). The Freundlich adsorption coefficient (Kf) was 54 L/kg with fitting parameter N equal to 0.874(4).

The Henry's Law constant for 1,3-dibromopropane has been measured as 8.88X10-4 atm-cu m/mole(1). This Henry's Law constant indicates that 1,3-dibromopropane is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6 days(SRC). 1,3-Dibromopropane's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 1,3-dibromopropane from dry soil surfaces exists(SRC) based upon its vapor pressure of 1.36 mm Hg at 25 °C(1).

GROUNDWATER: 1,3-Dibromopropane was identified, not quantified, in groundwater near a chemical plant in Switzerland(1).

Occupational exposure to 1,3-dibromopropane may occur through inhalation and dermal contact with this compound at workplaces where 1,3-dibromopropane is produced or used. (SRC)

The metabolism of 1,3-dibromopropane had been investigated in the rat. Two conjugated metabolites have been isolated from the urine and identified as S-(3-hydroxypropyl)cysteine and N-acetyl-S-(3-hydroxypropyl)cysteine. An oxidation product, identified as beta-bromolactic acid, has been isolated as a urinary metabolite. 1,3-dibromopropane is not excreted unchanged in expired air or in the urine. Approx. 15% of the dose (100 mg/kg) is excreted as metabolic products over 50 h and 3.5% as CO2 within 6 h, indicating that oxidation is the main route of detoxication.

1,3-dibromopropane

Grade: Technical, CP

Propane, 1,3-dibromo-: ACTIVE