Trimethyl phosphite

124.076

124.08

204-471-5

26Q0321ZDG

1556

6513

2329

DTXSID4026979

Colorless liquid

2920901100

27.7

-0.93

Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in water. Vapors heavier than air. Used to make other chemicals.

1.0520 g/cm³ @ Temp: 20 °C

-78 °C

111.5 °C

82°F

n20/D 1.408(lit.)

Reacts

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Never allow product to get in contact with water during storage. Storage class (TRGS 510): Flammable liquids.

Vapour pressure, kPa at 25°C: 3.2

Relative vapour density (air = 1): 4.3

Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.

Irritating, pungent, oily, pyridine-like odor

Air sensitive|Pour point: less than -60 °C|Hydrolyzed by hot water|Decomposes to dimethyl phosphite and methanol in water|Hydroxyl radical reaction rate constant = 7.10X10-10 cu cm/molec-sec at 25 °C

Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol.

Sulfonates, Phosphonates, and Thiophosphonates, Organic

Highly Flammable

As soon as TRIMETHYL PHOSPHITE contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).

250 °C

Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.

42.5 kJ/mol at 302-342 °C

III

3

UN 2329 3/PG 3

1

R10;R22;R36/37/38

S26

TH1400000

Xn:Harmful;

Fireproof. Separated from oxidants and strong bases.

Stable under recommended storage conditions.

P261-P280-P305 + P351 + P338

H226-H302-H315-H318-H335

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.|SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.|Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.|Principles and methods for destruction of chemical weapons: ... "Destruction of chemical weapons" means a process by which chemicals are converted in an essentially irreversible way to a form unsuitable for production of chemical weapons, and which in an irreversible manner renders munitions and other devices unusable as such. ... Each ... /nation/ shall determine how it shall destroy chemical weapons, except that the following processes may not be used: dumping in any body of water, land burial or open-pit burning. It shall destroy chemical weapons only at specifically designated and appropriately designed and equipped facilities. ... Each ... /nation/ shall ensure that its chemical weapons destruction facilities are constructed and operated in a manner to ensure the destruction of the chemical weapons; and that the destruction process can be verified under the provisions of this Convention.

Incompatible materials: Oxidizing agents, strong bases.|In the exothermic reaction /of trimethylplatinum(iv)azide tetramer/ with trimethyl phosphite to give cis-dimethyl-bis(trimethyl phosphito)platinum, the azide must be added in small portions with stirring. Addn of the phosphite to solid azide led to a violent explosion, probably involving the transitory by-product methyl azide.|Contact between /magnesium perchlorate & trimethyl phosphite/ caused violent explosions on several occasions. (Methyl perchlorate may have been formed).|Magnesium perchlorate, water [Note: Reacts (hydrolyzes) with water].|For more Hazardous Reactivities and Incompatibilities (Complete) data for TRIMETHYL PHOSPHITE (7 total), please visit the HSDB record page.

Organization for the Prohibition of Chemical Weapons; Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and Their Destruction. The Chemical Weapons Convention (CWC) is an international treaty which bans the development, production, stockpiling, and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors.[Available from, as of November 12, 2008: http://www.opcw.org]

Special Hazards of Combustion Products: Toxic fumes of PO x (USCG, 1999)|Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 23 °C explosive vapour/air mixtures may be formed.|Flammable - 3rd degree, Reactive - 2nd degree

|Danger|H226 (99.22%): Flammable liquid and vapor [Warning Flammable liquids]|P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 129 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P301+P312, P314, P330, and P501|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P314, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P312, P314, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Eye/face protection: Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves.|Body Protection: Complete suit protecting against chemicals. Flame retardant antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|For more Personal Protective Equipment (PPE) (Complete) data for TRIMETHYL PHOSPHITE (7 total), please visit the HSDB record page.|(See protection codes)

Flammable liquid when exposed to heat, flame, or oxidizers.

Suitable extinguishing media: Dry powder.|Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.|To fight fire, use water, foam, fog, /carbon dioxide/.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Do not flush with water.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning.|ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.|For more Preventive Measures (Complete) data for TRIMETHYL PHOSPHITE (8 total), please visit the HSDB record page.

/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 130 FLAMMABLE LIQUIDS (Non-Polar/Water-Immiscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for TRIMETHYL PHOSPHITE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. Trimethyl phosphite is included on the dangerous goods list.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. Trimethyl phosphite is included on the dangerous goods list.

... An irritant to eyes, skin & upper resp system.

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 2 ppm (10 mg/cu m).

Personal protection: self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible.

Fireproof. Separated from oxidants and strong bases.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is severely irritating to the eyes and skin.

Animal tests show that this substance possibly causes toxicity to human reproduction or development.

NO open flames, NO sparks and NO smoking. Above 23 °C use a closed system, ventilation and explosion-proof electrical equipment.

AVOID EXPOSURE OF (PREGNANT) WOMEN!

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures.

IDENTIFICATION AND USE: Trimethyl phosphite (TMP) is a colorless liquid. It is used primarily as an intermediate in the manufacture of pesticides. It is also used as a fireproofing agent in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst. HUMAN EXPOSURE AND TOXICITY: Examination of 179 employees involved in manufacturing of TMP failed to reveal any indications of ocular changes or other adverse effects on worker health associated with occupational exposure to trimethyl phosphite. It is only moderately toxic by oral ingestion and an irritant to eyes, skin and upper respiratory system. ANIMAL STUDIES: Topical application of trimethyl phosphite produced moderately severe but persistent irritation on rabbit skin. Instillation of undiluted trimethyl phosphite into the rabbit eye caused severe ocular irritation and swelling, which lasted for several days. No permanent damage to the eye could be detected. Marked mortality (> 70%) /was demonstrated/ among rats exposed at 600 ppm, 6 hours/day, 5 days/week for 4 weeks. Ten percent of the rats exposed at 300 ppm also died. Gross histological evidence of lung inflammation was observed in the animals exposed at 600 ppm, but no such changes occurred in those subjected to 300 or 100 ppm. Clinical signs of ocular irritation occurred in the animals exposed at 100 ppm or higher concentrations. Severe cataract developed in the 600 ppm exposure group, and mild cataracts from 300 ppm; 100 ppm exposures caused mild, reversible "striate opacities" of the lenses of a few animals. TMP was administered by gavage to pregnant rats at rates of 16, 49, or 164 mg/kg/day, on gestation Days 6 through 15. Acetyl salicylic acid (250 mg/kg/day) was also administered to a group of rats as a positive control. Teratologic evaluation revealed gross fetal abnormalities, skeletal defects, and soft tissue defects at a dose rate of 164 mg/kg/day of trimethyl phosphite, but not at the two lesser rates. An increased frequency of fetal resorption was also observed at 164 mg/kg/day. Trimethyl phosphite was genotoxic in three separate mouse lymphoma assays, either with or without microsomal activation. Trimethyl phosphite was also positive in a battery of Drosophila melanogaster mutagenicity assays and in a bacterial DNA damage/repair suspension assay using various strains of Escherichia coli and Salmonella typhimurium. Trimethyl phosphite failed to show evidence for genetic toxicity in Salmonella and Saccharomyces strains, in a cell transformation assay, in a bacterial DNA repair assay (Escherichia coli, Salmonella typhimurium) or in two Salmonella/mammalian-microsome preincubation assays.

LD50 Rabbit dermal 2600 mg/kg|LD50 Rat oral 2500-2890 mg/kg|LD50 Rat oral 1600 mg/kg|LD50 Mouse ip 4180 mg/kg|For more Non-Human Toxicity Values (Complete) data for TRIMETHYL PHOSPHITE (7 total), please visit the HSDB record page.

Trimethyl phosphite's production and use as an intermediate, especially for production of pesticides(1), as a fireproofing agent in the production of textiles, as an intermediate in production of flame-retardant polymers for polyurethane foams, and as a catalyst(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Trimethyl phosphite hydrolyzes rapidly in the presence of water(1,2) and therefore, adsorption to soil, volatilization from moist soil surfaces, and biodegradation are not expected to be important fate processes(SRC). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(3). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(3). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(3). Trimethyl phosphite is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 24 mm Hg at 25 °C(4). Dimethyl phosphite, an hydrolysis product of trimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable(1).|AQUATIC FATE: Trimethyl phosphite hydrolyzes rapidly in the presence of water(1,2) and therefore, adsorption to sediment, volatilization from water surfaces, bioconcentration and biodegradation are not expected to be important fate processes(SRC). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(1,2). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(3). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(3). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(3). Dimethyl phosphite, an hydrolysis product of trimethyl phosphite, reached 48% of its theoretical BOD in 4 weeks in the Japanese MITI test indicating it is inherently biodegradable, but not readily biodegradable(1).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethyl phosphite, which has a vapor pressure of 24 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethyl phosphite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 33 minutes(SRC), calculated from its rate constant of 7.1X10-10 cu cm/molecule-sec at 25 °C(3). Trimethyl phosphite does not absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of trimethyl phosphite with photochemically-produced hydroxyl radicals is 7.1X10-10 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 33 minutes at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol(3,4). The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC). In acid solution (pH=4) triethyl phosphite hydrolyzes immediately forming diethyl phosphite and ethanol(5). At pH 7, triethyl phosphite hydrolyzes completely within 20 minutes; after 3 hours 89.3% diethyl phosphite and 10.7% monoethyl phosphite are formed(5). At pH 9, the half-life of triethyl phosphite in water is approximately 5.1 hours; 70% of the substance remains unhydrolyzed after 3 hours(5). The UV absorption spectrum of trimethyl phosphite suggests that trimethyl phosphite does not absorb at wavelengths >290 nm(6) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Bioconcentration is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1). Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite (CAS 868-85-9) which has a reported low bioconcentration in fish(2).

Adsorption to soils or suspended solids and sediment in water is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1).

Volatilization from water surfaces or moist soil is not expected to be an important fate process(SRC) because trimethyl phosphite reacts (hydrolyzes) in water(1). Trimethyl phosphite is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 24 mm at 25 °C(1).

According to the 2012 TSCA Inventory Update Reporting data, 1 reporting facility estimates the number of persons reasonably likely to be exposed during the manufacturing, processing, or use of trimethyl phosphite (121-45-9) in the United States as <10 workers; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH has statistically estimated that 14,191 workers (6,311 of these were female) were potentially exposed to trimethyl phosphite in the US(1). Occupational exposure to trimethyl phosphite may occur through inhalation and dermal contact with this compound at workplaces where trimethyl phosphite is produced or used(SRC). Exposure of the general population to trimethyl phosphite is unlikely since it is used as a chemical intermediate and it is expected to hydrolyze rapidly in the environment(SRC).|With respect to employee health protection, /it has been concluded that/...long term, low level exposures to trimethyl phosphite vapors are not likely to produce any adverse effects if workroom air concentrations are maintained well below the level of subjective irritation.|Analysis of air in.../plants engaged in manufacture of trimethyl phosphite/ in 1979 indicated average exposures generally between 0.3 and 4 ppm, with occasional values as high as 15 ppm. Examination of 179 employees in these plants failed to reveal any indications of ocular changes or other adverse effects on worker health associated with occupational exposure to /Trimethyl phosphite/.

Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, immediately flush the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/EPIDEMIOLOGY STUDIES/ Analyses of workplace air /from a plant engaged in the manufacture of trimethyl phosphite revealed concentrations averaging up to 8 ppm in 1969 and 1971. More thorough studies in this and another facility in 1979 indicated average exposures generally between 0.3 and 4 ppm, with occasional values as high as 15 ppm. Examination of 179 employees in these plants failed to reveal any indications of ocular changes or other adverse effects on worker health associated with occupational exposure to trimethyl phosphite.|/OTHER TOXICITY INFORMATION/ It is only moderately toxic by oral ingestion and an irritant to eyes, skin and upper respiratory system. No information of chronic toxicity of vapors. Exposure of workers during its manufacture and handling may involve low-level inhalation of vapors.

trimethyl phosphite

The substance can be absorbed into the body through the skin and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, upper respiratory system; dermatitis; In Animals: teratogenic effects

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

Eyes, skin, respiratory system, reproductive system

JC Schumacher Co, EXTREMA, 99% grade

All other basic organic chemical manufacturing|Phosphorous acid, trimethyl ester: ACTIVE|/The Chemical Weapons Convention (CWC) is an international treaty which bans the development, production, stockpiling, and transfer or use of chemical weapons. The Convention mandates the destruction and prohibition of chemical weapons and related facilities and provides for restrictions on international trade in toxic chemicals and precursors./ The Convention's monitoring and verification measures involve submission of declarations regarding ... /Schedule 1, 2, and 3 chemicals/ and inspections by the Organization for the Prohibition of Chemical Weapons of the facilities where these chemicals are produced. ... Schedule 3 chemicals ... /may/ have been stockpiled or used as weapons, but ... are produced /and used/ in large quantities for purposes not prohibited by the Convention (2). Trimethyl phosphite is listed in the CWC Annex on Chemicals under Schedule 3 (1).

Fire Hazards -> Flammable - 3rd degree, Reactive - 2nd degree