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4-Acetamidobenzenesulfonyl chloride

4-Acetamidobenzenesulfonyl chloride structure

CAS No:
121-60-8
Formula:
C8H8ClNO3S
Chemical Name:
4-Acetamidobenzenesulfonyl chloride
Synonyms:
Benzenesulfonyl chloride,4-(acetylamino)-;Sulfanilyl chloride,N-acetyl-;4-(Acetylamino)benzenesulfonyl chloride;Acetanilide-p-sulfonyl chloride;p-(Acetylamino)benzenesulfonyl chloride;ASC;Dagenan chloride;4-Acetamidophenylsulfonyl chloride;N4-Acetylsulfanilyl chloride;p-Acetamidobenzenesulfonyl chloride;4′-(Chlorosulfonyl)acetanilide;p-Acetamidophenylsulfonyl chloride;4-Acetamidobenzenesulfonyl chloride;4-Chlorosulfonylacetanilide;p-(Chlorosulfonyl)acetanilide;N-Acetylsulfanilyl chloride;4-(Acetylamino)phenylsulfonyl chloride;N-Acetyl-p-aminobenzenesulfonyl chloride;NSC 127860;4-Acetamidobenzene-1-sulfonyl chloride;N-(4-Chlorosulfonylphenyl)acetamide;p-Acetylaminophenylsulfonyl chloride
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

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Description

OFF-WHITE TO SLIGHTLY GREY GRANULAR CRYST. POWDER

ASC has been investigated for the screening of Patients Undergoing Screening or Surveillance Colonoscopy.

4-Acetamidobenzenesulfonyl chloride Basic Attributes

Molecular Weight：

233.67

Exact Mass：

233.67

BRN：

746676

EC Number：

204-485-1

UNII：

LIX4M9AIVM

NSC Number：

127860

DSSTox ID：

DTXSID8026981

Color/Form：

NEEDLES FROM BENZENE; PRISMS FROM BENZENE-CHLOROFORM|THICK, LIGHT TAN PRISMS FROM BENZENE|LIGHT TAN TO BROWNISH POWDER OR FINE CRYSTALS

HScode：

29242995

Characteristics

PSA：

71.6

XLogP3：

1.55

Appearance：

White to cream-beige Granular Crystalline Powder or Crystals

Density：

1.2977 (rough estimate)

Melting Point：

149 °C

Boiling Point：

426.8±28.0 °C(Predicted)

Flash Point：

211.9±24.0 °C

Refractive Index：

1.6300 (estimate)

Water Solubility：

H2O: SLIGHTLY soluble ;VERY SOL IN ETHER, ALCOHOL; SOL IN HOT CHLOROFORM; soluble IN HOT BENZENE

Storage Conditions：

-20°C

Toxicity：

Oral-rat LD50:>2300mg/kg;Oral-Mouse LD50: 1600 mg/kg

Flammability characteristics：

Flammable; decomposes by heating and releases highly toxic nitrogen oxides, sulfur oxides and chloride fumes

Odor：

SLIGHT ODOR OF ACETIC ACID

Experimental Properties：

DECOMP IN WATER

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 3261 8/PG 2

wgk germany：

hazard class code：

22-34-37

safety instructions：

26-36/37/39-45-28B

RTECS Number：

DB8837500

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261-P280-P305 + P351 + P338-P310

Hazard Statements：

H314-H335

GHS Classification：

|Danger|H314 (51.61%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P261, P264, P271, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 187 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Irritations：

IRRITANT TO SKIN, EYES, & MUCOUS MEMBRANES OF NOSE & THROAT.

Toxicity

Toxicity class：

moderately toxic

Drug Information

Human Toxicity Excerpts：

IRRITANT TO SKIN, EYES, AND MUCOUS MEMBRANES OF NOSE AND THROAT.

MeSH Entry Terms：

4-AAB-SC cpd

4-Acetamidobenzenesulfonyl chloride Use and Manufacturing

Methods of Manufacturing

Acetanilide chlorosulfonation The following are two examples of industrial operations. Operation Add 67.5 kg of acetamidobenzene to 290 kg of chlorosulfonic acid with stirring, control the feeding temperature below 15°C, gradually increase the temperature to 60°C after addition, keep stirring for 2 h, and then gradually add the reactant to ice water to dilute , Keep the temperature below 10 ℃, filter, rinse with ice water until the Congo red test paper is neutral. Get acetamidobenzenesulfonyl chloride. Operation Acetamidobenzene was added to chlorosulfonic acid evenly below 20°C. By weight, acetanilide: chlorosulfonic acid = 1:5.26, and reacted at 50 ± 2°C for 3 hours. After being left for 8h, about 20℃ below, add appropriate amount of water to decompose excess chlorosulfonic acid, the temperature does not exceed 28℃, a little cold, filter, wash the filter cake to pH=3-4, to get acetamidosulfonyl chloride. The yield was 83%. This product is not suitable for long-term storage. As an intermediate product of medicine and dye production, the content is 30%.

Uses

Intermediate in the preparation of sulfanilamide and its derivatives.

Production

(1977) PROBABLY GREATER THAN 4.54X10+6 GRAMS|(1979) PROBABLY GREATER THAN 4.54X10+6 GRAMS

Consumption Patterns：

ESSENTIALLY 100% AS A CHEMICAL INTERMEDIATE

Manufacturing Info：

Benzenesulfonyl chloride, 4-(acetylamino)-: ACTIVE|BENZENE AND ETHER ARE POOR SOLVENTS FOR PURIFICATION BY RECRYSTALLIZATION. MUCH BETTER RESULTS ARE OBTAINED BY USING CHLOROFORM OR ETHYLENE DICHLORIDE. COMPARE NORTHEY, SULFONAMIDES (NEW YORK, 1948) P 12.

Computed Properties

Molecular Weight:233.67
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:232.9913420
Monoisotopic Mass:232.9913420
Topological Polar Surface Area:71.6
Heavy Atom Count:14
Complexity:301
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Aniline

Acetic acid

Hydrochloric acid

Chlorosulfonic acid

Downstream Products

Sulfamethazine

Recommended Suppliers of 4-Acetamidobenzenesulfonyl chloride

Hefei Heyu Chemical New Materials Co., Ltd Contact Supplier

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N-Acetylsulfanilyl chloride 121-60-8

CAS No.: 121-60-8

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

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N-Acetylsulfanilyl chloride

CAS No.: 121-60-8

Grade: industrial Grade

Content: 98%

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NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

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Manufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment Chemicals

N-Acetylsulfanilyl chloride

CAS No.: 121-60-8

Grade: Industrial Grade

Content: 99%

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Guide of 4-Acetamidobenzenesulfonyl chloride

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Material
Downstream Products
Recommended Suppliers
Latest News
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4-Acetamidobenzenesulfonyl chloride

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