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Acridine Orange base

Acridine Orange base structure

CAS No:
494-38-2
Formula:
C17H19N3
Chemical Name:
Acridine Orange base
Synonyms:
3,6-Acridinediamine,N3,N3,N6,N6-tetramethyl-;Acridine,3,6-bis(dimethylamino)-;3,6-Acridinediamine,N,N,N′,N′-tetramethyl-;N3,N3,N6,N6-Tetramethyl-3,6-acridinediamine;C.I. 46005B;Brilliant Acridine Orange E;C.I. Solvent Orange 15;3,6-Di(dimethylamino)acridine;Waxoline Orange A;3,6-Bis(dimethylamino)acridine;Acridine Orange base;Acridine orange free base;NSC 194350;Solvent Orange 15;3-N,3-N,6-N,6-N-Tetramethylacridine-3,6-diamine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

ChEBI: A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination.

Acridine orange free base is a member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. It has a role as a fluorochrome and a histological dye. It is a member of aminoacridines, an aromatic amine and a tertiary amino compound.|A cationic cytochemical stain specific for cell nuclei, especially DNA. It is used as a supravital stain and in fluorescence cytochemistry. It may cause mutations in microorganisms.

Acridine Orange base Basic Attributes

Molecular Weight：

265.35

Exact Mass：

265.35

EC Number：

610-452-6

UNII：

F30N4O6XVV

NSC Number：

194350

DSSTox ID：

DTXSID60197783

Characteristics

PSA：

19.4

XLogP3：

4.65

Appearance：

BROWN POWDER

Density：

1.2±0.1 g/cm3

Melting Point：

181-182 °C

Boiling Point：

469℃

Flash Point：

237℃

Refractive Index：

1.710

Water Solubility：

0.00 M

Toxicity：

Subcutaneous-mouse LD50: 250 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

wgk germany：

safety instructions：

22-24/25

RTECS Number：

AR7600000

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)|Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)

MeSH Entry Terms：

3,6-Bis(dimethylamino)acridine

Acridine Orange base Use and Manufacturing

A fluorescent nucleic acid binding dye which interacts with both DNA and RNA.

Computed Properties

Molecular Weight:265.35
XLogP3:3.4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:265.157897619
Monoisotopic Mass:265.157897619
Topological Polar Surface Area:19.4
Heavy Atom Count:20
Complexity:298
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 494-38-2

Grade: Pharmaceutical Grade

Content: 99%

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