Guvacine
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Guvacine
structure -
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CAS No:
498-96-4
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Formula:
C6H9NO2
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Chemical Name:
Guvacine
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Synonyms:
3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-;Nicotinic acid,1,2,5,6-tetrahydro-;1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid;1,2,5,6-Tetrahydronicotinic acid;Guvacine
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CAS No:
Description
ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.
Guvacine is a alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring. It has a role as a plant metabolite and a GABA reuptake inhibitor. It is a beta-amino acid, a tetrahydropyridine, an alpha,beta-unsaturated monocarboxylic acid, a pyridine alkaloid and a secondary amino compound.|Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant affinity at GABA receptors.
Characteristics
49.33000
0.72
1.2±0.1 g/cm3
295 °C (decomp)
280.8±35.0 °C at 760 mmHg
123.6±25.9 °C
1.518
Soluble in water, and almost insoluble in 100% alcohol, ether, chloroform, and benzene.
Store at RT
0.000983mmHg at 25°C
Drug Information
There is no approved indication for guvacine.
Experimental studies are still being investigated to determine all of the physiological effects of guvacine.
Experimental studies are still being investigated to determine the exact mechanisms of action of guvacine. What is known is that guvacine binds selectively to presynaptic GABA reuptake transporters and prevents the reuptake of GABA, but has no affinity for GABA postsynaptic receptors.
guvacine
Computed Properties
Molecular Weight:127.14
XLogP3:-2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:127.063328530
Monoisotopic Mass:127.063328530
Topological Polar Surface Area:49.3
Heavy Atom Count:9
Complexity:151
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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