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(+)-1,2-Propanediol

(+)-1,2-Propanediol structure

CAS No:
4254-15-3
Formula:
C3H8O2
Chemical Name:
(+)-1,2-Propanediol
Synonyms:
1,2-Propanediol,(2S)-;1,2-Propanediol,(S)-(+)-;1,2-Propanediol,(S)-;(2S)-1,2-Propanediol;L-(+)-Propylene glycol;(+)-(S)-1,2-Propanediol;d-Propylene glycol;3-Deoxy-sn-glycerol;(S)-1,2-Propanediol;L-1,2-Propanediol;(S)-(+)-Propylene glycol;L-(+)-Propanediol;(+)-1,2-Propanediol;(S)-(+)-Propane-1,2-diol;1,2(S)-Propanediol;(S)-2-Hydroxy-1-propanol;(S)-Propylene glycol;(S)-2-Hydroxypropanol;(2S)-Propane-1,2-diol;(S)-Propane-1,2-diol;(2S)-Propane-1,2-diol
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Colorless to light yellow liqui Propylene glycol is a clear, colorless, viscous, practically odorless liquid, with a sweet, slightly acrid taste resembling that of glycerin.

Solid

(S)-propane-1,2-diol is a propane-1,2-diol. It has a role as a human metabolite and an Escherichia coli metabolite. It is an enantiomer of a (R)-propane-1,2-diol.|(S)-propane-1,2-diol is a clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.

(+)-1,2-Propanediol Basic Attributes

Molecular Weight：

76.09

Exact Mass：

76.09

UNII：

942194N4TD

HScode：

2905399090

Characteristics

PSA：

40.5

XLogP3：

-0.9

Appearance：

Solid

Density：

1.0364 g/cm³ @ Temp: 20 °C

Melting Point：

-59ºC

Boiling Point：

88.7 °C @ Press: 13 Torr

Flash Point：

107.2±0.0 °C

Refractive Index：

1.430

Water Solubility：

soluble

Storage Conditions：

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

Marks：

Precautionary statement(s)：

P264, P280, P305+P351+P338, P33, P313

Hazard Statements：

H319

GHS Classification：

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 3 companies from 2 notifications to the ECHA C&L Inventory.

(+)-1,2-Propanediol Use and Manufacturing

Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.

Computed Properties

Molecular Weight:76.09
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:76.052429494
Monoisotopic Mass:76.052429494
Topological Polar Surface Area:40.5
Heavy Atom Count:5
Complexity:20.9
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes