2-Methylpentanedinitrile

108.14100

108.14

224-923-5

3276

DTXSID4025612|DTXSID5029344

Liquid at ambient temperatures.

2926909090

47.58000

1.44986

D,l-2-methylglutaronitrile is an amber liquid. (NTP, 1992)

0.9548 g/cm³ @ Temp: 20 °C

-45 °C

263 °C

>230 °F

n20/D 1.434(lit.)

10 to 50 mg/mL at 70.7° F (NTP, 1992)

0.0051 mm Hg at 25 deg C

Henry's Law constant= 2.97X10-8 atm-cu m/mole (est)

Water soluble.

Nitriles

Nitriles, such as D,L-2-METHYLGLUTARONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

III

6.1(b)

3276

3

R20/21/22

S36/37

YV8140000

Xn

P260-P280-P284-P301 + P310-P310

H301 + H311-H330

This compound is combustible. (NTP, 1992)

|Danger|H301+H311 (95%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]|P260, P264, P270, P271, P280, P284, P301+P310, P302+P352, P304+P340, P310, P312, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this compound can be controlled by dry chemical, carbon dioxide, and/or Halon extinguishers. (NTP, 1992)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3276 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

2-Methylpentanedinitrile is produced as a by-product during the production of adiponitrile(1). Therefore, release of 2-methylpentanedinitrile to the environment may occur during the production of adiponitrile. Since 2-methylpentanedinitrile is used as a solvent and intermediate for the manufacture of other chemicals(2), environmental release may occur during these uses(SRC).

TERRESTRIAL FATE: Based on expected slow hydrolysis(2) of 2-methylpentanedinitrile in water, hydrolysis may be unimportant in soil. The log Koc of 1.03 estimated from log Kow(1,4) indicates that 2-methylpentanedinitrile should be very mobile in soil(3,SRC). The vapor pressure of 0.0051 mm Hg at 25 °C(5) suggests volatilization from soil may not be rapid(SRC).|AQUATIC FATE: Based on hydrolysis rates of a monosubstituted organic nitrile, hydrolysis of 2-methylpentanedinitrile may not be important in environmental waters(2,SRC). From the estimated Henry's Law constant(4) and an estimation method(1), the volatilization half-life of 2-methylpentanedinitrile from a model river has been estimated to be 1259 days(1,SRC). Therefore, volatilization from water should not be important. The estimated log Koc of 1.03(1) indicates that adsorption of 2-methylpentanedinitrile to suspended solids and sediments in water should not be important(3). The estimated bioconcentration factor of 0.2(1) suggests that bioconcentration of 2-methylpentanedinitrile in aquatic organisms should be unimportant(SRC).|ATMOSPHERIC FATE: Based on a vapor pressure of 0.0051 mm of Hg(4), 2-methylpentanedinitrile should be found predominantly in the vapor phase in the atmosphere(3,SRC). In the atmosphere, vapor phase 2-methylpentanedinitrile should react with photochemically produced hydroxyl radicals. Based on an estimation method(1), the rate constant for the reaction of 2-methylpentanedinitrile with hydroxyl radicals has been estimated to be 1.208X10-12 cu-cm/molecule-sec(1). Assuming the daily average concn of hydroxyl radicals in the atmosphere as 5X10+5/cu-cm(2), the half-life for this reaction has been estimated to be 13.3 days. Based on a high water solubility estimated from log Kow(5) and a regression equation(6), the removal of atmospheric 2-methylpentanedinitrile by wet deposition should be important(SRC).

Organic nitriles are generally susceptible to chemical hydrolysis under acid and basic conditions; but based on very slow hydrolysis of cyano group in organic nitriles(2), the hydrolysis of 2-methylpentanedinitrile in water and moist soil should not be important. The rate constant for the reaction of vapor phase 2-methylpentanedinitrile with hydroxyl radicals has been estimated to be 1.208X10-12 cu-cm/molecule-sec by an estimation method(3,SRC). Assuming the daily average concn of hydroxyl radicals in the atmosphere of 5X10+5/cu-cm(4), the half-life for this reaction has been estimated to be 13.3 days(SRC).

Based on an estimated log Kow of -0.644(2) and a regression equation(1), the bioconcentration factor for 2-methylpentanedinitrile has been estimated to be 0.2. Therefore, bioconcentration of 2-methylpentanedinitrile in aquatic organisms should not be important(3,SRC).

Based on an estimated log Kow value of -0.644(1) and a regression equation(2), a log Koc value of 1.03 has been estimated for 2-methylpentanedinitrile. This value indicates that 2-methylpentanedinitrile should be highly mobile in soil(3) and the adsorption of 2-methylpentanedinitrile to suspended solids and sediments in water should be unimportant(SRC).

A Henry's Law constant of 2.97X10-8 atm-cu m/mole has been estimated for 2-methylpentanedinitrile by the bond contribution method(1). Based on this value, the volatilization of 2-methylpentanedinitrile from a model river of depth 1 m, flowing at 1 m/sec and a wind speed of 3 m/sec has been estimated to be 1259 days(2,SRC). Therefore, volatilization should not be important in water(SRC).

Since 2-methylpentanedinitrile is a liquid at ambient temperatures with low vapor pressure, dermal exposure to this compound may be the most probable route of exposure during its use as solvent and intermediate in the production of other compounds(1,SRC).|Workers using 2-methylpentanedinitrile as solvent and intermediate in the production of other chemicals(1) are the most likely people for exposure to this compound(SRC).

ACUTE/CHRONIC HAZARDS: This compound is readily absorbed through the skin. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

methylglutaronitrile

Pentanedinitrile, methyl-: INACTIVE|All other basic organic chemical manufacturing|Pentanedinitrile, 2-methyl-: ACTIVE