(±)-Stylopine
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(±)-Stylopine
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CAS No:
4312-32-7
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Formula:
C19H17NO4
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Chemical Name:
(±)-Stylopine
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Synonyms:
4H-Bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizine,6,7,12b,13-tetrahydro-;Berbine,2,3:9,10-bis(methylenedioxy)-,(±)-;6,7,12b,13-Tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizine;(±)-Tetrahydrocoptisine;(RS)-Stylopine;dl-Stylopine;(±)-Stylopine;dl-Tetrahydrocoptisine;Tetrahydrocoptisine;2,3:9,10-Bis(methylenedioxy)berbine;NSC 110382;NSC 404529;Chelidamine;7461-02-1;11028-74-3;16846-33-6
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CAS No:
Description
Tetrahydrocoptisine is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.IC50 value:Target:in vitro: THC significantly inhibited LPS-induced TNF-α, interleukin-6(IL-6) and nitric oxide (NO) production. THC inhibited the production of TNF-α and IL-6 by down-regulating LPS-induced IL-6 and TNF-α mRNA expression [1].in vivo: Pretreatment with THC (i.p.) inhibited the paw and ear edema in the carrageenan-induced paw e
(±)-Stylopine Use and Manufacturing
dl-Stylopineis is an isoquinoline alkaloid isolated from the whole plant of Argemone mexicana. (S)-Stylopine is an important intermediate in the biosynthesis of benzophenanthridine alkaloids, such as Sanguinarine.
Computed Properties
Molecular Weight:323.3
XLogP3:3
Hydrogen Bond Acceptor Count:5
Exact Mass:323.11575802
Monoisotopic Mass:323.11575802
Topological Polar Surface Area:40.2
Heavy Atom Count:24
Complexity:502
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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