2-Methoxypropanoic acid

Sodium methoxide in methanol (25percent, 16 mL) was added to a stirred solution of 2- bromopropionic acid (19.6 mmol) in methanol (5 mL) under nitrogen. The reaction was heated at 50 Preparation of 2-methoxypropanoic acidSodium methoxide in methanol (25percent, 16 mL) was added to a stirred solution of 2- bromopropionic acid (19.6 mmol) in methanol (5 mL) under nitrogen. The reaction was heated at 50 C under nitrogen overnight. The reaction was then concentrated under vacuum. The residue was brought to pH 1 by the addition of 1 N aqueous HCl and this solution was then extracted with ethyl acetate three times (70 mL, 25 mL, 10 mL). The combined organic layer was dried (Na2SO4) and then concentrated under vacuum to yield the title compound as a colorless oil 2.04 g (99percent) which was of sufficient purity to be used without purification. 1H NMR (CD3OD) ' 3.67 (q, IH), 3.33 (s, 3H), and 1.33 ppm(d, 3H).15.3 g of 2-bromopropionic acid and 100 mL of methanol were introduced into a three-necked flask, 19.3 g of sodium methoxide (28percent methanol solution) was added dropwise while stirring at room temperature, and the mixture was refluxed at 50 DEG C for 12 hours. The reaction solution was concentrated under reduced pressure, and 100 mL of 1 N dilute hydrochloric acid and 100 mL of ethyl acetate were added to extract and separate the organic layer. The resulting organic layer was concentrated to obtain 10.4 g of Compound A2-2-12.50 g sodium hydride (60 percent in mineral oil) are dissolved in 600 ml tetrahydrofurane and cooled to 0Intermediate M : Preparation of JV-[4-(chloromethyl)pyridin-2-yl]-2-methoxypropanamide; Step 1: Preparation of 2-methoxypropanoic acid; Sodium methoxide in methanol (25percent, 16 mL) was added to a stirred solution of 2-bromopropionic acid (19.6 mmol) in methanol (5 mL) under nitrogen. The reaction washeated at 50 °C under nitrogen overnight. The reaction was then concentrated under vacuum. The residue was brought to pH 1 by the addition of 1 N aqueous HC1 and this solution was then extracted with ethyl acetate three times (70 mL, 25 mL, 10 mL). The combined organic layer was dried (NazSC^) and then concentrated under vacuum to yield the title compound as a colorless oil 2.04 g (99percent) which was of sufficient purity to be used without purification. 'HNMR (CD

Molecular Weight:104.10
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:104.047344113
Monoisotopic Mass:104.047344113
Topological Polar Surface Area:46.5
Heavy Atom Count:7
Complexity:69.3
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes