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    Home > Pharmaceutical Intermediates > Sleep Disorder Agents > 2-Chloro-4,6-dimethylpyrimidine
    2-Chloro-4,6-dimethylpyrimidine structure

    2-Chloro-4,6-dimethylpyrimidine

    • CAS No:

      4472-44-0

    • Formula:

      C6H7ClN2

    • Synonyms:

      NSC49016;AKOSBBS-00002114;IFLAB-BBF2130-0005;CHEMBRDG-BB4900312;2-chloro-4,6-dimethyl-pyrimidin;2-CHLORO-4,6-DIMETHYLPYRIMIDINE;2-Chloro-3,5-dimethylpyrimidine;4,6-DiMethyl-2-chloropyriMidine;2-Chloro-4,6-dimethyl-1,3-diazine;Pyrimidine,2-chloro-4,6-dimethyl-

    • China Export:

      From 2018.11 to 2019.11, total export volume of 2-Chloro-4,6-dimethylpyrimidine from China was 35,610,569KG while total export value was $1,117,619,760. The biggest proportion of exporting volume in the last 12 months was 11.77% in 2019.03.

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    Basic Attributes

    • 4472-44-0

    • C6H7ClN2

    • 142.59

    • 142.029770

    • 25.8 A^2

    • 2

    • RZVPFDOTMFYQHR-UHFFFAOYSA-N

    • 2

    • 0

    • 0.33

    • 0

    Characteristics

    • White to yellow Powder, Crystalline Powder or Low Melting Solid

    • 1,03g/cm

    • 34-36

    • 212 °C

    • 110℃

    • 1428

    • 2-8°C

    Safety Information

    • IRRITANT

    • 2933599090

    • UN 2265

    • 20/21/22-36/37/38-22

    • 26-36-37

    • UV8000000

    • Xi,Xn

    • P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

    • H302

    • Irritant

    Production Methods

    The mixture of compound 2 (1998 mg, 12.44mmol) and phosphorus oxychloride (20 mL) was refluxed for 10 h. The remaining phosphorusoxychloride was evaporated to get a brown oil in the flask. The mixture was cooled in an icebath, and concentrated aqueous KOH solution was added dropwise cautiously with stirring, until the litmus paper showed pH value that is approximately 8. Diethyl ether (30 mL) wasadded, and the mixture was stirred for 2.5 h. The water layer was extracted with Et2O (3 × 30mL) and EtOAc (3 × 30 mL). The organic layers were combined, washed with brine, driedover Na2SO4, filtered and concentrated under reduced pressure. The resulting yellow liquidwas put in an ice bath under vacuum to afford compound 3 (1606 mg, 91percent yield) as yellowcrystals. 1H NMR (400 MHz, DMSO-d6) δ 7.33 (s, 1H), 2.42 (s, 6H).A mixture of 4, 6-dimethyl-2-hydroxypyrimidine hydrochloride (20.0 g, 0.125 mol) and phosphorous oxychloride (110 ml) was refluxed for 10 h after which time the residual phosphorous oxychloride was removed in vacuum. Reference Example 129: 2-Chloro-4, 6-dimethyl-pyrimidme. A suspension of 4, 6-dimethyl-lH-pyrimidin-2-one hydrochloride (3.0 g, 18.75 mmol) in dry POCl

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    Material and Products

    China 2-Chloro-4,6-dimethylpyrimidine Export Data

    Data referenced from General Administration of Customs,P.R.China

    2018.11-2019.11 China - America  2-Chloro-4,6-dimethylpyrimidine Export Data

    From 2018.11 to 2019.11, total export volume of 2-Chloro-4,6-dimethylpyrimidine from China to America was 1,696,532KG while total export value was $121,959,783. The biggest proportion of exporting volume in the last 12 months was 14.50% in 2019.01.

    2018.11-2019.11 China 2-Chloro-4,6-dimethylpyrimidine Export Data

    From 2018.11 to 2019.11, total export volume of 2-Chloro-4,6-dimethylpyrimidine from China was 35,610,569KG while total export value was $1,117,619,760. The biggest proportion of exporting volume in the last 12 months was 11.77% in 2019.03.

    2018.11-2019.11 TOP10 Purchasing Countries' Export Data of Chinese 2-Chloro-4,6-dimethylpyrimidine

    From 2018.11 to 2019.11, China has exported 2-Chloro-4,6-dimethylpyrimidine to 120 countries in total. Country ranks by import volume from high to low is India, Germany, Iran, America, Japan, United Kingdom, Netherlands, Vietnam, Denmark, Singapore. The highest export volume was China to India, accounting for 11.08% of the total volume of China.

    Check Export Data for More Purchasing Countries

    Purchasing Country Export Volume(KG) Export Percentage Export Value($)

    India

    7,110,534

    11.08%

    244,583,865

    Germany

    4,707,416

    7.33%

    83,278,504

    Iran

    2,125,739

    3.31%

    41,079,869

    America

    1,696,532

    2.64%

    121,959,783

    Japan

    1,366,761

    2.13%

    25,494,629

    United Kingdom

    1,172,087

    1.83%

    40,820,094

    Netherlands

    1,108,778

    1.73%

    18,010,932

    Vietnam

    1,025,562

    1.60%

    33,465,278

    Denmark

    980,521

    1.53%

    11,426,872

    Singapore

    924,867

    1.44%

    8,335,186

    Taiwan

    840,441

    1.31%

    14,112,106

    Italy

    835,158

    1.30%

    42,695,379

    Korea

    743,886

    1.16%

    23,688,948

    Brazil

    728,317

    1.13%

    31,427,608

    France

    558,503

    0.87%

    25,360,861

    Pakistan

    552,520

    0.86%

    21,073,608

    Mexico

    543,175

    0.85%

    21,769,279

    Belgium

    528,606

    0.82%

    25,198,184

    Indonesia

    503,682

    0.78%

    12,018,780

    Argentina

    474,987

    0.74%

    21,838,665

    Thailand

    453,914

    0.71%

    11,158,365

    Jordan

    394,981

    0.62%

    6,744,231

    Spain

    391,517

    0.61%

    19,255,579

    Russia

    391,062

    0.61%

    17,191,186

    Bangladesh

    364,491

    0.57%

    15,092,587

    South Africa

    342,454

    0.53%

    8,259,903

    Saudi Arabia

    331,523

    0.52%

    4,090,992

    Colombia

    315,361

    0.49%

    7,645,951

    Turkey

    303,617

    0.47%

    10,717,100

    Switzerland

    288,337

    0.45%

    18,516,252

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