Z-GLU(OME)-OH
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Z-GLU(OME)-OH
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CAS No:
4652-65-7
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Formula:
C14H17NO6
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Chemical Name:
Z-GLU(OME)-OH
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Synonyms:
Z-GLU(OME)-OH;Z-L-Glu(Me)-OH;CBZ-GLU(OME)-OH;Z-GLUTAMICACID(OME)-OH;5-MethylN-Cbz-L-glutaMate;Z-L-GLUTAMICACIDY-METHYLESTER;Cbz-L-glutamicacid4-methylester;MethylN-carbobenzoxy-L-glutamate;5-MethylN-Carbobenzoxy-L-glutaMate;Z-L-GLUTAMICACIDGAMMA-METHYLESTER
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CAS No:
Z-GLU(OME)-OH Use and Manufacturing
N-CBZ-glutamic acid 5-methyl ester (25 g, 0.1 mol) was dissolved in t- butyl acetate (250ML) and 70% perchloric acid (1.5 ML) was added. The solution was stoppered, stirred and left to stand at room temperature for 48 hours. The flask was opened carefully and added dropwise to a saturated solution of NAHCO3. When the addition was complete, the mixture was extracted with ethyl acetate and the organic phase washed with water and brine, dried over magnesium sulfate and evaporated to dryness. The oily product was purified by column chromatography over silica gel eluted with hexane ethyl acetate (4: 1).
Computed Properties
Molecular Weight:295.29
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:295.10558726
Monoisotopic Mass:295.10558726
Topological Polar Surface Area:102
Heavy Atom Count:21
Complexity:365
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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