2,4-DIBROMO-5-NITROPYRIDINE

2, 4-Dibromo-5-nitropyridine Phosphorous oxybromide (5.73 g, 20 mmol) was added to a suspension of the product from Step 1 (1.70 g, 10 mmol) in acetonitrile (20 mL) at rt then heated to reflux for 3 h. The reaction mixture was cooled and carefully poured onto ice and sat. aq. K2C03 then extracted with EtOAc. The organic extracts were combined, washd with water and brine, dried (MgS04), filtered and concentrated to dive the title compound (2.1 g, 75 percent) as a dark solid.Step 2.2, 4-Dibromo-5-nitropyridine Phosphorous oxybromide (5.73 g, 20 mmol) was added to a suspension of the product from Step 1 (1.70 g, 10 mmol) in acetonitrile (20 mL) at rt then heated to reflux for 3 h. The reaction mixture was cooled and carefully poured onto ice and sat. aq. K2C03 then extracted with EtOAc. The organic extracts were combined, washd with water and brine, dried (MgS04), filtered and concentrated to dive the title compound (2.1 g, 75 percent) as a dark solid.To a solution of 2-hydroxy-4-methoxy-5-nitropyridine (10 g, 59 mmole) in acetonitrile (60 mL) was added POBrInto a 250 mL 3 -necked round-bottom flask purged and maintained with nitrogen was added a solution of 4-chloro-5-nitropyridin-2-ol (1 1.5 g, 65.9 mmol) in CHA CH3CN (5 mL) solution of

2,4-Dibromo-5-nitropyridine is a tri-substituted pyridine derivative used in the preparation of AKT kinase inhibitors and antihypertensive agents.

Molecular Weight:281.89
XLogP3:2.4
Hydrogen Bond Acceptor Count:3
Exact Mass:281.84625
Monoisotopic Mass:279.84830
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:161
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes