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Nitracrine

Nitracrine structure

CAS No:
4533-39-5
Formula:
C18H20N4O2
Chemical Name:
Nitracrine
Synonyms:
1,3-Propanediamine,N1,N1-dimethyl-N3-(1-nitro-9-acridinyl)-;Acridine,9-[[3-(dimethylamino)propyl]amino]-1-nitro-;1,3-Propanediamine,N,N-dimethyl-N′-(1-nitro-9-acridinyl)-;N1,N1-Dimethyl-N3-(1-nitro-9-acridinyl)-1,3-propanediamine;9-[[3-(Dimethylamino)propyl]amino]-1-nitroacridine;1-Nitro-9-(3-dimethylaminopropylamino)acridine;Nitracrine;1,3-Propanediamine N1,N1-dimethyl-N3-(1-nitro-9-acridinyl)-
Categories:
Organic Chemistry > Quinones

Description

Nitracrine is a member of acridines.|Nitracrine is an acridine derivative with potential cytostatic and antitumor activities. Although the exact mechanism of action has not been fully elucidated, nitracrine induces the unwinding of supercoiled DNA and binds to the DNA through intercalation, forming drug-DNA adducts and DNA interstrand crosslinks. This inhibits RNA synthesis, protein production, cell growth, DNA replication and cell proliferation; altogether, this may promote apoptosis. Since cancer cells have increased metabolism and proliferate at an increased rate, nitracrine may induce tumor cell apoptosis.|Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.

Nitracrine Basic Attributes

Molecular Weight：

324.384

Exact Mass：

324.38

UNII：

712MLZ30SB

DSSTox ID：

DTXSID90196481

NCI Thesaurus Code：

C694

Characteristics

PSA：

XLogP3：

3.7

Density：

1.2155 (rough estimate)

Melting Point：

134.5 °C

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)

MeSH Entry Terms：

C 283

Computed Properties

Molecular Weight:324.4
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:324.15862589
Monoisotopic Mass:324.15862589
Topological Polar Surface Area:74
Heavy Atom Count:24
Complexity:426
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Nitracrine

CAS No.: 4533-39-5

Grade: Industrial Grade

Content: 99.0%

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