Acid Green 25

622.58

622.045654

224-546-6

8J6RDU8L9X

DTXSID2024903

Dark blue-green powder|Green powder

3204120000

189

2.00 (est)

D & c green 5 appears as fine black or green powder. (NTP, 1992)

235-238 °C(lit.)

H2O: 36 g/L (20 ºC)

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

7.3X10-25 mm Hg at 25 deg C

Oral-rat LD50: >10000 mg/kg; Oral-Mouse LD50: 6700 mg/kg

The warehouse is ventilated and low-temperature and dry; stored dry powder, foam, sand, carbon dioxide, and spray water separately from the food raw materials; combustible; burning produces toxic nitrogen oxides, sulfur oxides, and sodium oxide fumes

Henry's Law constant = 3.2X10-29 atm-cu m/mol at 25 °C (est)

Dull blue color in concentrated H2SO4, turning turquoise on dilution|Hydroxyl radical reaction rate constant = 1.7X10-10 cu cm/molec-sec at 25 °C (est)

Slightly soluble in water.

Acids, Carboxylic

D & C GREEN 5 is incompatible with strong oxidizing agents. (NTP, 1992).

UN 3077 9 / PGIII

2

51/53-36

24/25-61-26

DB5044000

N

Warehouse ventilated, low temperature and dry

Stable under normal temperatures and pressures.

P273

H411

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

All batches of this color additive when used in a drug shall meet the specifications, uses and restrictions, and labeling regulations contained in 21 CFR Part 74 and be certified in accordance with regulations in 21 CFR Part 80.|All batches of this color additive when used in cosmetics shall meet the specifications, uses and restrictions, and labeling regulations contained in 21 CFR Part 74 and be certified in accordance with regulations in 21 CFR Part 80.|A batch of this straight color may be certified, in accordance with 21 CFR Part 82, for use in drugs and cosmetics, if such batch conforms to the requirements of 21 CFR 82.5 and to the specifications in 21 CFR Part 82.

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

|Warning|H315 (21.55%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P391, and P501|Aggregated GHS information provided by 391 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

practically nontoxic

LD50 Mouse oral 6700 mg/kg|LD50 Rat oral >10,000 mg/kg bw|LD50 Rat oral >3160 mg/kg bw|LD50 Dog oral >1000 mg/kg bw

D&C Green No. 5's production and use as a dye(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Acid dyes, such as, typically exhibit very low solubilities in octanol and have water solubilities that exceed 100 g/L. Therefore, these compounds would be expected to remain in the water column in the aquatic environment and show little affinity for organic matter(1) which suggests a potential to leach in soil(SRC). Volatilization of D&C Green No. 5 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.2X10-29 atm-cu m/mole(SRC), using a fragment constant estimation method(2). D&C Green No. 5 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.3X10-25 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). D&C Green No. 5, present at 100 mg/L, exhibited <25% elimination after 3 hours and overall <70% elimination in 42 days using an activated sludge inoculum at 0.5 mg/L dry material in the modified static test which suggests the dye may be considered to be partially biodegradable(5).|AQUATIC FATE: Acid dyes, such as D&C Green No. 5, typically exhibit very low solubilities in octanol and have water solubilities that exceed 100 g/L. Therefore, these compounds would be expected to remain in the water column in the aquatic environment and show little affinity for organic matter(1). Volatilization from water surfaces is not expected(2) based upon an estimated Henry's Law constant of 3.2X10-29 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of 2.00(3) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). D&C Green No. 5, present at 100 mg/L, exhibited <25% elimination after 3 hours and overall <70% elimination in 42 days using an activated sludge inoculum at 0.5 mg/L dry material in the modified static test which suggests the dye may be considered to be partially biodegradable(5).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), D&C Green No. 5, which has an estimated vapor pressure of 7.3X10-25 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase D&C Green No. 5 may be removed from the air by wet or dry deposition(SRC). D&C Green No. 5 absorbs light at wavelengths of 608 nm(4), and therefore may be susceptible to direct photolysis by sunlight(SRC).

Acid dyes, such as D&C Green No. 5, readily dissociate in water(1). D&C Green No. 5 absorbs light at wavelengths of 608 nm(2), and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 3 was calculated in fish for D&C Green No. 5(SRC), using an estimated log Kow of 2.00(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Acid dyes, such as D&C Green No. 5, typically exhibit very low solubilities in octanol and have water solubilities that exceed 100 g/L. Therefore, these compounds would be expected to remain in the water column in the aquatic environment and show little affinity for organic matter(1). Estimation methods are not currently available to adequately predict the Koc of most dyes(SRC).

The Henry's Law constant for D&C Green No. 5 is estimated as 3.2X10-29 atm-cu cm/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that D&C Green No. 5 is expected to be essentially nonvolatile from water surfaces(2). D&C Green No. 5's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected occur(SRC). FD&C Green No. 2 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.3X10-25 mm Hg(SRC), determined from a fragment constant method(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 76,430 workers (39,772 of these were female) were potentially exposed to D&C Green No. 5 sodium in the US(1). Occupational exposure to D&C Green No. 5 may occur through dermal contact with this compound at workplaces where D&C Green No. 5 is produced or used(SRC).

Impurities and accompanying contaminants:

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and upper respiratory tract. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion, or skin absorption. It is an irritant of the skin, eyes, mucous membranes and upper respiratory tract. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

6,6'-(1,4-anthraquinonylenediimino)di-m-toluenesulfonic acid disodium salt

Trade names: Acid Green Anthraquinone; Alizarin Cyanine Green F; Japan Green 201

Benzenesulfonic acid, 2,2'-[(9,10-dihydro-9,10-dioxo-1,4-anthracenediyl)diimino]bis[5-methyl-, sodium salt (1:2): ACTIVE|The name D&C Green No. 5 can be used only when applied to batches of color that have been certified according to United States certification regulations. The CFTA Adopted Name for non-certified batches of this color is Acid Green 25.|Color additives were initially regulated in the United States under the U.S. Department of Agriculture's (USDA) Bureau of Chemistry. In 1906, the Food and Drugs Act was passed by Congress, which prohibited the use of poisonous or deleterious colors in confectionery and the coloring or staining of food to conceal damage or inferiority. In 1927, responsibility of the Food and Drugs Act was transferred to FDA. Increasing government oversight, the Federal Food, Drug, and Cosmetic Act (FFDCA) was passed in 1938 and established the three following categories for colors: FD&C: colors used in foods, drugs and cosmetics; D&C: colors used in drugs and cosmetics when in contact with mucous membranes or ingested; and Ext. D&C: colors used in products applied externally.

EPA Safer Chemical Functional Use Classes -> Colorants|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues|Cosmetics -> Cosmetic colorant; Hair dyeing