Spaglumic acid
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Spaglumic acid
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CAS No:
4910-46-7
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Formula:
C11H16N2O8
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Chemical Name:
Spaglumic acid
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Synonyms:
L-Glutamic acid,N-acetyl-L-β-aspartyl-;Glutamic acid,N-(N-acetyl-L-β-aspartyl)-,L-;Glutamic acid,N-(N-acetyl-L-β-aspartyl)-;L-Glutamic acid,N-(N-acetyl-L-β-aspartyl)-;N-Acetyl-L-β-aspartyl-L-glutamic acid;Spaglumic acid;β-Spaglumic acid;β-NAAG
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CAS No:
Description
Spaglumic acid is a peptide.|Spaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis. Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis.
Characteristics
170
-1.96
1.5±0.1 g/cm3
113-115 °C (decomp)
769.5±60.0 °C at 760 mmHg
419.1±32.9 °C
1.540
−20°C
Drug Information
Used in patients with allergic conjunctivitis.
Spaglumic acid is a mast cell stabilizer. Mast cells are involved in producing an allergic response by releasing inflammatory mediators such as histamine. Mast cell stablizers block the release of histamine and other mediators by inhibiting mast cell degranulation, which is the process of releasing these mediators. Inhibition occurs through inhibition of specific calcium channels to stabilize the mast cell and prevent degranulation.
beta-NAAG
Computed Properties
Molecular Weight:304.25
XLogP3:-2.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:304.09066547
Monoisotopic Mass:304.09066547
Topological Polar Surface Area:170
Heavy Atom Count:21
Complexity:448
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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