Triethylene glycol monobutyl ether

206.279

206.28

205-592-6

T1J4684X95|OC116GRO69

0965

164915

DTXSID7021520

Colorless liquid

2909499000

47.92000

0.08

Liquid

0.9890 g/cm³ @ Temp: 20 °C

-35 °C

278 °C @ Press: 760 Torr

127.9±21.8 °C

1.438

Solubility in water: miscible

1 @ 20°C

Explosive limits , vol% in air: 0.8-3.8

Mild smelling

Henry's Law constant = 9.50X10-14 atm-cu m/mol at 25 °C (est

Percent in saturated air: 0.00032 at 25 °C; 1 ppm = 8.44 mg/cu m at 25 °C, 760 mm Hg; 1 mg/L = 118.5 ppm at 25 °C, 760 mm Hg|Wt/gal at 25 °C = 8.30 lb|Hydroxyl radical reaction rate constant = 5.15X10-11 cu cm/molec-sec at 25 °C (est)

176 BTU/lb at 190 °C, 50 mm Hg

NONH for all modes of transport

R41

S26-S36/37/39-S46-S39

KJ9450000

Xi:Irritant;

Stable. Incompatible with acids, strong bases, strong oxidizing agents.

P280-P305 + P351 + P338 + P310

H318

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Glycol ethers, glycols, ketones, and alcohols undergo violent decomposition in contact with 68-72% perchloric acid

Combustible.

|Danger|H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310|H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|Aggregated GHS information provided by 3458 companies from 4 notifications to the ECHA C&L Inventory.|Warning|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Combustible

Explosive limits , vol% in air: 0.8-3.8

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Found to be highly irritating in the rabbit eye in two separate studies.Rabbit eyes were necrosed by instillation of 0.02 mL. Minor to moderate injury resulted from instillation of 0.005 mL.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is irritating to the eyes. The substance is mildly irritating to the skin.

The substance defats the skin, which may cause dryness or cracking.

NO open flames.

Use ventilation.

Protective gloves.

Wear safety goggles.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Triethylene glycol monobutyl ether has been identified in the effluents from the following industries: paint and ink (3438 ng/uL extract), printing and publishing (3868 ng/uL extract), and organic chemicals (160 ng/uL extract)(1).

Triethylene glycol monobutyl ether was identified in a sample of fine organometallic automobile brake lining wear particles at a concentration of 181.7 ug/g of particle sampled(1).

LD50 Wistar Rat oral 5300 mg/kg (male)|LD50 Carworth-Wistar Rat oral 6.73 mL/Kg bw (males)|LD50 Rabbit dermal 3.54 mL/kg bw (males)

Triethylene glycol monobutyl ether's production and use as a plasticizer intermediate(1), a solvent for cellulose nitrate, cellulose ethers, chlorinated rubber, poly(vinyl acetate), colophony, many other natural and synthetic resins, stoving chemicals, wood paints, pharmaceutical and cosmetic preparations, as well as drying greases and oils(3), as a solubilizer for mutually incompatible liquids(3), in the production of household and metal cleansing agents as well as for wood preservation(3), in cutting and hydraulic oils, production of inks(3), as a leveling agent(3), in the leather auxiliaries industry(3), and in the chemical, textile, and transportation industries(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol monobutyl ether is expected to have very high mobility in soil(SRC). Volatilization of triethylene glycol monobutyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.5X10-14 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Triethylene glycol monobutyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 2.5X10-3 mm Hg(4). The theoretical BODs for triethylene glycol monobutyl ether are 0, 5, and 24% for 5, 10 and 20 days, respectively(5), suggesting that triethylene glycol monobutyl ether is expected to biodegrade slowly in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol monobutyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.5X10-14 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 0.02(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The theoretical BODs for triethylene glycol monobutyl ether are 0, 5 and 24% for 5, 10 and 20 days, respectively(8), triethylene glycol monobutyl ether is expected to biodegrade slowly in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triethylene glycol monobutyl ether, which has a vapor pressure of 2.5X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase triethylene glycol monobutyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7.5 hours(SRC), calculated from its rate constant of 5.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Alcohols and ethers do not contain chromophores that absorb at wavelengths >290 nm and therefore triethylene glycol monobutyl ether is not expected to be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of triethylene glycol monobutyl ether with photochemically-produced hydroxyl radicals has been estimated as 5.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 7.5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Triethylene glycol monobutyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Alcohols and ethers do not contain chromophores that absorb at wavelengths >290 nm and therefore triethylene glycol monobutyl ether is not expected to be susceptible to direct photolysis by sunlight(3).

An estimated BCF of 3 was calculated in fish for triethylene glycol monobutyl ether(SRC), using an estimated log Kow of 0.02(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of triethylene glycol monobutyl ether can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that triethylene glycol monobutyl ether is expected to have very high mobility in soil(SRC).

The Henry's Law constant for triethylene glycol monobutyl ether is estimated as 9.5X10-14 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that triethylene glycol monobutyl ether is expected to be essentially nonvolatile from water surfaces(2). Triethylene glycol monobutyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 2.5X10-3 mm Hg(3).

DRINKING WATER: Triethylene glycol monobutyl ether was listed as a contaminant found in advanced drinking water treatment in Lake Tahoe, CA, Pomona, CA, and Orange County, CA(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 25,310 workers (50 of these are female) are potentially exposed to triethylene glycol monobutyl ether in the US(1). Occupational exposure to triethylene glycol monobutyl ether may occur through inhalation and dermal contact with this compound at workplaces where triethylene glycol monobutyl ether is produced or used(SRC). Monitoring and use data indicate that the general population may be exposed to triethylene glycol monobutyl ether via ingestion of contaminated drinking water, and dermal contact with products containing triethylene glycol monobutyl ether(SRC).

Human abdominal whole skin (2.54 cm sq) was mounted in a glass diffusion apparatus (at 30 +/- 1 degree C) and the diffusion of triethylene glycol monobutyl ether was monitored during a 12-hr period using gas chromatography (n=6). The integrity of the epidermal membranes was first assessed by measuring permeability of membranes to tritiated water. Epidermal membranes displaying permeability constants greater than 1.5 x 10E-3 cm/hr were deemed to have been damaged during preparation and were rejected. The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 ug/cm sq/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

The substance can be absorbed into the body by inhalation of its aerosol.

Redness. Dry skin.

Redness. Pain.

All other basic organic chemical manufacturing|Ethanol, 2-[2-(2-butoxyethoxy)ethoxy]-: ACTIVE