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DL-Histidine

DL-Histidine structure

DL-Histidine 

structure
  • CAS No:

    4998-57-6

  • Formula:

    C6H9N3O2

  • Chemical Name:

    DL-Histidine

  • Synonyms:

    Histidine;Histidine,DL-;DL-Histidine;(±)-Histidine;1H-Imidazole-4-alanine;2-Amino-3-(1H-imidazol-5-yl)propanoic acid;2-Amino-3-(5-imidazolyl)propanoic acid;2-Amino-3-(1H-imidazol-4-yl)propanoic acid;184709-11-3

  • Categories:

    Biochemical Engineering  >  Amino Acids and Proteins

Description

white to slightly yellow crystalline powder


Histidine is an alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3. It has a role as a metabolite. It is an alpha-amino acid, a member of imidazoles, an aromatic amino acid and a polar amino acid. It contains a 1H-imidazol-4-ylmethyl group. It is a conjugate base of a histidinium(1+). It is a conjugate acid of a histidinate(1-).

DL-Histidine Basic Attributes

155.15

155.15

225-660-9

620356|137773

2933290090

Characteristics

92

-3.2

white crystals

1.4±0.1 g/cm3

828 °C

458.9°C at 760 mmHg

231.3±25.9 °C

1.615

0.5 M HCl: soluble

Store at RT.

Safety Information

NONH for all modes of transport

3

22-36/37/38

22-24/25-36/37-26

Xn

Stable under normal temperatures and pressures.

Drug Information

poly(L-histidine)

DL-Histidine Use and Manufacturing

Methods of Manufacturing

Using L-histidine hydrochloride as raw material, adding acetic anhydride under alkaline conditions for acylation reaction, extracting with ethanol and precipitating with excess acetone to obtain acetyl-DL-histidine; Reflux for several hours, ethanol precipitation to obtain crude DL-histidine, and then crystallization purification to obtain pure product.

Uses

Used for biochemical research.

Histidine: ACTIVE

Computed Properties

Molecular Weight:155.15
XLogP3:-3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:155.069476538
Monoisotopic Mass:155.069476538
Topological Polar Surface Area:92
Heavy Atom Count:11
Complexity:151
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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