 Home > Encyclopedia > Rosoxacin

Rosoxacin

Rosoxacin structure

CAS No:
40034-42-2
Formula:
C17H14N2O3
Chemical Name:
Rosoxacin
Synonyms:
3-Quinolinecarboxylic acid,1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-;1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid;Rosoxacin;Acrosoxacin;Roxadyl;Eradacil;Eracin;Winuron;Eradacin;Win 35213;NSC 146617;1-Ethyl-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxylic acid
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Rosoxacin (Acrosoxacin) is a potent and orally active quinolone antibiotic. Rosoxacin (Acrosoxacin) has antibacterial activities against a broad spectrum of Gram negative bacteria including Neisseria gonorrhoeae (MIC90=0.03mg/ml). Rosoxacin has the potential for urinary tract infections treatment[1].

Solid

Rosoxacin is a quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid that is substituted by an ethyl group at position 1 and by a pyridin-4-yl group at position 7. An antibacterial drug, active against Neisseria gonorrhoeae, it has been used for treating urinary tract infections and certain sexually transmitted diseases. It has a role as an antibacterial drug and an antiinfective agent. It is a quinolone antibiotic, a quinolinemonocarboxylic acid and a member of pyridines.|Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients. Rosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, especially anaphylactic shock.

Rosoxacin Basic Attributes

Molecular Weight：

294.309

Exact Mass：

294.30

EC Number：

254-758-4

UNII：

3Y1OT3J4NW

NSC Number：

146617

DSSTox ID：

DTXSID90193091

ATC Code：

J - Antiinfectives for systemic use

HScode：

2933990090

Characteristics

PSA：

70.5

XLogP3：

Appearance：

Solid

Density：

1.317g/cm3

Melting Point：

290 °C

Boiling Point：

500.8ºC at 760 mmHg

Flash Point：

256.7ºC

Refractive Index：

1.633

Water Solubility：

1.02e-01 g/L

Drug Information

Drug Indication：

For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.

Pharmacology：

Rosoxacin is a nonfluorinated quinolone antibiotic. Its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

MeSH：

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)

Mechanism of Action：

Rosoxacin binds to and inhibits the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

MeSH Entry Terms：

acrosoxacin

Rosoxacin Use and Manufacturing

Antibacterial.

Computed Properties

Molecular Weight:294.30
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:294.10044231
Monoisotopic Mass:294.10044231
Topological Polar Surface Area:70.5
Heavy Atom Count:22
Complexity:482
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes