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Phenol red

Phenol red structure

CAS No:
143-74-8
Formula:
C19H14O5S
Chemical Name:
Phenol red
Synonyms:
Phenol,4,4′-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis-;Phenol,4,4′-(3H-2,1-benzoxathiol-3-ylidene)di-,S,S-dioxide;Phenol,4,4′-(3H-2,1-benzoxathiol-3-ylidene)bis-,S,S-dioxide;3H-2,1-Benzoxathiole,phenol deriv.;4,4′-(1,1-Dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[phenol];3,3-Bis(p-hydroxyphenyl)-2,1-3H-benzoxathiole 1,1-dioxide;α-Hydroxy-α,α-bis(p-hydroxyphenyl)-o-toluenesulfonic acid γ-sultone;Phenol red;Phenolsulfonephthalein;Phenolsulfonphthalein;Sulfonphthal;Phenolsulphonphthalein;3H-2,1-Benzoxathiole,3,3-bis(4-hydroxyphenyl)-,1,1-dioxide;Fenolipuna;PSP (indicator);Sulphental;Sulphonthal;PSP;TF-R 2;NSC 10459;2877-88-5
Categories:
Cosmetic Ingredient > Buffering

Description

Phenol red is 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney. It has a role as a two-colour indicator, an acid-base indicator and a diagnostic agent. It is a 2,1-benzoxathiole, a member of phenols, a sultone and an arenesulfonate ester.|Phenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions.|Red dye, pH indicator, and diagnostic aid for determination of renal function. It is used also for studies of the gastrointestinal and other systems.

Phenol red Basic Attributes

Molecular Weight：

354.37600

Exact Mass：

354.38

EC Number：

205-609-7

UNII：

I6G9Y0J1OJ

NSC Number：

10459

DSSTox ID：

DTXSID8022408

ATC Code：

V - Various

HScode：

29349990

Characteristics

PSA：

92.21000

XLogP3：

Density：

1.477 g/cm3

Melting Point：

>300 °C

Boiling Point：

562.8ºC at 760 mmHg

Flash Point：

79ºC

Refractive Index：

1.4334 (18ºC)

Water Solubility：

H2O: 0.77 g/L

Storage Conditions：

Store at RT.

Vapor Pressure：

2.84E-13mmHg at 25°C

Safety Information

Packing level：

I; II; III

Transport codes：

NONH for all modes of transport

hazard class code：

R36/37/38

safety instructions：

S26-S37/39

RTECS Number：

SJ7490000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Drug Information

MeSH：

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)|Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)

MeSH Entry Terms：

Phenol Red

Phenol red Use and Manufacturing

Uses

Used as an acid-base indicator, the color range of pH: 6.8 (sulfur) -8.4 (red). Also used in biochemical research. Purpose: Acid-base indicator, color change range pH: 6.8 (yellow) -8.4 (red). Full measurement of blood carbon dioxide, preparation of disaccharide iron urea medium indicator in bacterial serum test. Its sodium salt is used to determine liver function. Also used in biochemical research.

Manufacturing Info：

Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis-: ACTIVE

Computed Properties

Molecular Weight:354.4
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:354.05619472
Monoisotopic Mass:354.05619472
Topological Polar Surface Area:92.2
Heavy Atom Count:25
Complexity:545
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Phenol

Zinc chloride

Downstream Products

Phenol

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