Disodium methylarsonate

183.94

183.90900

205-620-7

7NK4BV40VN

3082

DTXSID4032665

Hydrated crystals containing 5H2O or 6H2O|Monoclinic spear-shaped plates from absolute alcohol|White crystalline solid

2931900090

63.19000

Kow = <10

1.04 g/cm³

>355 °C

165ºC

In water, 4.32X10+5 mg/l @ 25 deg C

Do not store near feed, food.

10-7 mm Hg @ 25 deg C

Oral-rat LD50: 821 mg/kg; Oral-Mouse LD50: 1150 mg/kg

Thermal decomposition of toxic arsenide gas

Pleasant acid taste

pKa1 = 4.1; pKa2 = 8.94

Hydrolysis to MSMA @ pH 6-7; decomposed by strong oxidizing and reducing agents|Colorless crystals /Hexahydrate/|Hygroscopic

NON-CORROSIVE TO IRON, RUBBER AND MOST PLASTICS|Mildly corrosive

III

6.1(b)

2759

22-50/53-23/25

26-61-60-45-28-20/21

PA2275000

Xn,N,T

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

/Decomposes/ slowly at elevated temperatures. Stable to hydrolysis.

P261, P264, P270, P271, P273, P301+P310, P301+P312, P304+P340, P311, P321, P330, P391, P403+P233, P405, P501

H301

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Arsenic or organo-arsenic containing wastewater treatment sludges from production of veterinary pharmaceuticals are poor candidates for incineration.

Can react vigorously with oxidizing materials; e.g. air, /chloride/.

|Danger|H301 (90.48%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Goggles or face shield, rubber or neoprene gloves, rubber apron.

NOT FLAMMABLE|Dangerous fire hazard by spontaneous chemical reaction. Ignites spontaneously in dry air. Can react vigorously with oxidizing materials; e.g. air, /chloride/.

Wear goggles and self contained breathing apparatus|Fire extinguishing media: Dry chemical, carbon dioxide.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Protective clothing to prevent contact with skin; chemical goggles.|Avoid skin contact or breathing spray mist. ... Keep children, domestic animals off treated areas until material washes into soil.

Slight eye, skin irritant.

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Disodium methanearsonate is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

The sorption of arsenic, phosphate, disodium methanearsonate, and the sodium salt of cacodylic acid by 16 Mississippi river alluvial flood plain soils is measured in a slurry experiment in which initial pH and molar solution concn for all four solutes are identical. Sorption of the two organoarsenical herbicides is strongly correlated with arsenate and phophate sorption, and sorption of all four species is strongly correlated with clay and iron oxide contents of the soils.

moderately toxic

LD50 RAT ORAL 8000 MG/KG /21% LIQUID/|LD50 MOUSE IV 316 MG/KG|LD50 MOUSE SC 3350 MG/KG|LD50 RABBIT IV 1240 MG/KG|For more Non-Human Toxicity Values (Complete) data for DISODIUM METHANEARSONATE (13 total), please visit the HSDB record page.

... FOUND RAPID LOSS OF HERBICIDAL ACTIVITY FROM DSMA APPLIED TO BOSKET SILT LOAM. MOST MARKED REDUCTION IN TOXIC RESIDUES OCCURRED BETWEEN INITIAL PLANTING DATE AND 16-WEEK REPLANTING DATE.|TERRESTRIAL FATE: Organoarsenicals, such as dimethylarsinic acid, methanearsonic acid, monosodium and disodium salts, and sodium cacodylate are adsorbed by clay soils. After rapid initial adsorption, changes occur which result in the redistribution of dimethylarsinic acid into a less soluble form associated with aluminium in the soil. Downward leaching of the methanearsonic acid salts has also been reported. The methanearsonic acid salts and dimethylarsinic acid are fixed by iron and aluminium in the soil, although not as strongly as inorganic arsenate.|REACTION OF ... DSMA ... EXAMINED IN ... PLANTS ... SINGLE RADIOACTIVE CMPD ... FOUND /IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS LEGUMINOSAE)/ IN HOT 80% ETHANOL EXTRACT. RF WAS 0.59 COMPARED TO 0.66 FOR STANDARD DSMA. CHEM ANALYSIS REVEALED THAT C-AS BOND REMAINED INTACT.

LOSS FROM PHOTODECOMPOSITION IN BASIC SOIL TYPES: NONE.

Leghorn hens (groups of 5) were fed a diet containing 200 ppm of the herbicide Angar 8100 (active principle disodium methylarsenate) for 30 days ... /until/ slaughter; a similar group was fed the same diet containing 2 g sunflower pectin. Considerable residues /were/ found in the former group, the level in tissue being 0.0250 mg/kg; however, addition of pectin to the diet produced a 30-80% decline, the level in tissue being 0.0047 mg/kg.

602.56 L/kg|TYPE OF CLAY MINERAL MAY BE RESPONSIBLE FOR DIFFERENT FIXATION TENDENCIES ... KAOLINITE REMOVED MUCH MORE DSMA FROM SOLN THAN DID VERMICULITE. SMALLER SIZE FRACTIONS OF AUGUSTA SILT LOAM ... ABSORBED LARGER PERCENTAGES OF MAA /METHANEARSONIC ACID/ PRESENT IN SOLUTION.|PHYTOTOXICITY IS ... AFFECTED BY LEACHING OF DSMA. IF ARSONATE IS APPLIED WITHIN 2 HR OF RAIN, LITTLE ABSORPTION WILL OCCUR AND LEACHING OF MAA /METHANEARSONIC ACID/ PROCEEDS.|... FOUND NO LEACHING OF DSMA IN DECATUR CLAY LOAM, WHILE 52% ... RECOVERED IN THE TWENTY 1 IN INCREMENTS OF LEACHATE FROM NORFOLK LOAMY SAND. MOVEMENT THROUGH NORFOLK LOAMY SAND OCCURRED AS BAND OF HIGH FRONTAL CONCN WHICH ... DECREASED IN DIRECTION OF ZONE OF APPLICATION.

NONE

CMPD INCL METHANEARSONIC ACID SODIUM SALTS; INJURIES WERE CAUSED PRIMARILY BY USE OF FAULTY EQUIPMENT, CARELESSNESS IN ITS OPERATION, IMPROPER USE OF PROTECTIVE EQUIPMENT. /METHANEARSONIC ACID SODIUM SALTS/|The National Occupational Hazard Survey conducted by NIOSH estimated that 1130 workers may be exposed to Disodium Methanearsonate; 100% from observed use of a tradename product known to contain this chemical.

Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)|An agent that causes the production of physical defects in the developing embryo. (See all compounds classified as Teratogens.)

USING (14)C LABELED DSMA, STUDIES SHOWED THAT DSMA .. READILY TAKEN UP BY BERMUDAGRASS FROM ... NUTRIENT SOLN BUT... SLOWLY FROM SOIL. ... ABOUT 25% ... TRANSLOCATED TO ROOTS & RHIZOMES WITHIN 5 DAYS. SMALL AMT OF CARBON DIOXIDE ... DETECTED. ... C-AS BOND REMAINED LARGELY INTACT ... .|EARLY REPORTS INDICATED ... DSMA ... NOT TRANSLOCATED IN PLANTS ... HOWEVER ... EXAMINED TRANSLOCATION OF AMMONIUM METHYLARSONATE TO SHOOTS OF SINGLE NUTSEDGE TUBERS & TO TERMINAL TUBER SHOOTS. ARSENIC WAS TRANSLOCATED ... LATERALLY TO TUBERS SEPARATED BY AT LEAST FOUR TUBERS FROM TUBER'S SHOOT ... . /AMMONIUM METHYLARSONATE/|... STUDIED TRANSLOCATION OF DSMA ... IN PURPLE NUTSEDGE FOLLOWING FOLIAR APPLICATION. ... STUDIES INDICATED ... APOPLASTIC & SYMPLASTIC MOVEMENT ... DSMA MOVED IN ... ACROPETAL & BASIPETAL DIRECTIONS ... ARSENIC ... ACCUMULATED IN TERMINAL TUBERS AFTER REPEATED APPLICATIONS.|... FOUND MOVEMENT OF ARSENIC INTO RHIZOMES AND FOLIAR REGROWTH OF JOHNSONGRASS FOLLOWING FOLIAR APPLICATION OF DSMA. ... FOUND ACROPETAL AND BASIPETAL TRANSLOCATION ... IN COASTAL BERMUDA GRASS. APPROXIMATELY 25% OF ARSENIC INTERCEPTED BY LEAVES ... TRANSLOCATED TO ROOTS AND RHIZOMES ... .|For more Absorption, Distribution and Excretion (Complete) data for DISODIUM METHANEARSONATE (12 total), please visit the HSDB record page.

... EXAMINED REACTION PRODUCTS OF DSMA ... IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS L). ... RADIOACTIVITY WAS ... DETECTED IN RESPIRATORY CARBON DIOXIDE FROM (14)C DSMA-TREATED PLANTS, INDICATING C-AS BOND DEGRADATION.|... TREATED ... BERMUDA GRASS (CYNODON DACTYLON LEGUMINOSAE PERS) WITH (14)C DSMA. MOLECULE REMAINED INTACT, BUT ... COMPLEXED. 80% HOT ETHANOL EXTRACT CONTAINED UNKNOWN ... LITTLE (14)C CARBON DIOXIDE (0.1%) ... FOUND IN RESPIRATORY CARBON DIOXIDE 10 DAYS AFTER TREATMENT.|Evolution of gaseous arsenic from DSMA-treated soil was a function of organic matter and moisture content. Greatest loss of arsenic was from soil containing 11% added organic matter and maintained under reduced conditions. The sorbed arsenic was predominantly in the form of iron arsenate. Aluminum arsenate was the next most abundant form.|Studies have identified the compound evolved from cultures of Penicillium brevicaule containing DSMA as trimethylarsine.|VOLUNTEERS INGESTED A SINGLE ORAL DOSE OF 500 MG ARSENIC AS DISODIUM METHANEARSONATE. AFTER 4 DAYS, 78% OF INGESTED ARSENIC WAS EXCRETED IN URINE. METHANEARSONATE IS 13% METHYLATED INTO DIMETHYLARSINATE.

ARSONIC ACID HERBICIDES ARE NOT GROWTH REGULATORS IN SENSE OF PLANT HORMONES. THEY ... ACT THROUGH ENZYME SYSTEMS TO INHIBIT GROWTH. THEY KILL ... SLOWLY; FIRST SYMPTOMS ARE ... CHLOROSIS, CESSATION OF GROWTH, & GRADUAL YELLOWING, THEN BROWNING FOLLOWED BY DEHYDRATION & DEATH. /ORGANOARSENICAL HERBICIDES/

Carcinogens

COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS; 9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.|ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE. TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALS; HOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN.|Toxic by ingestion and inhalation.

disodium methanearsonate

USEPA/OPP Pesticide Code 013802; Trade Names: Ansar 8100; Arrhenal; Ansar DSMA Liquid; Dinate; Crab-E-Rad; Chipco Crab Kleen; Arsinyl; Sodar; Methar; Drexel DSMA Liquid; Di-Tac; Ansar 184; Weed-E-Rad; Versar DSMA-LQ; Calar-E-Rad; Dal-E-Rad; Jon-Trol; Namate.|DISODIUM METHYLARSONATE COMBINED WITH EQUIMOLAR AMT OF MERCURY SALICYLATE IS CALLED ENESOL, WHITE POWDER, SOLUBLE IN WATER.|ANSAR 8100--WATER SOLUBLE POWDER 81% ACTIVE INGREDIENT; ANSAR DSMA LIQUID--AQ SOLN 21% ACTIVE INGREDIENT ... .|THE PENTAHYDRATE CONTAINS ABOUT 28% ARSENIC, BUT THE COMMERCIAL MATERIAL USUALLY HAS A PURITY OF ONLY 50% (14% ARSENIC).|For more Formulations/Preparations (Complete) data for DISODIUM METHANEARSONATE (6 total), please visit the HSDB record page.

MSMA and DSMA were introduced by Ansul Chemical Co (which no longer exists) ... under US patent as trade mark 'Ansar' ... .|... MAA /METHANEARSONIC ACID/ AND DSMA WERE NOT GOOD SOIL STERILIZERS. ... DSMA CONTROLLED DALLIS GRASS (PASPALUM DILATATUM ... AND GOOSEGRASS (ELEUSINE INDICA (L) GAERTN). ... DSMA GREATLY ENHANCED WEED CONTROL ACTIVITY OF ... DICRYL.|WEEDS CONTROLLED BY ... DSMA: AGERATUM, TROPIC; ANGELTONGRASS; BAMBOO GRASS; BARNYARDGRASS; BINDWEED, FIELD; BLACKSEEDGRASS; BUFFELGRASS; BULRUSH; CARELESS WEED; CHEATGRASS; CHICKWEED, FIELD; CHICKWEED, MOUSEEAR; CHICKWEED, STICKY; CHOMPIPE; COCKLEBUR, COMMON; CRABGRASS, HAIRY ... .|WEEDS CONTROLLED BY ... DSMA: ... CRABGRASS, LARGE; CRABGRASS, SMALL; CRABGRASS,SMOOTH; DALLISGRASS; DROPSEED, INDIAN; FIDDLENECK; FINGERGRASS, SWOLLEN; FOXTAIL, GIANT; FOXTAIL, GREEN; FOXTAIL, YELLOW; GERMAN WEED; GROMWELL;GROUNDCHERRY, LONGLEAF; HEMPWEED, CLIMBING; HENBIT ... .|For more General Manufacturing Information (Complete) data for DISODIUM METHANEARSONATE (12 total), please visit the HSDB record page.

IN FORMULATED PRODUCTS CONTAINING INTERFERING ACIDS, DETERMINE ARSENIC CONTENT BY STANDARD WET DIGESTION PROCEDURE AND CONVERT TO DSMA CONTENT.|METHOD FOR QUANTITATING METHANEARSONATE IONS IN RUNOFF (WATER & SUSPENDED SEDIMENT): FLAMELESS ATOMIC ABSORPTION.

Health Hazards -> Carcinogens